Table 2. Effect of the minor allele of rs10783846 on body composition and strength in females and males at baseline.
| rs10783486 | ||||||
|---|---|---|---|---|---|---|
| female | male | |||||
| GG | AA/AG | P value | GG | AA/AG | P value | |
| n | 24 | 31 | 25 | 27 | ||
| Weight | 62.3±11.2 | 65.8±10.6 | 0.240 | 79.5 (73.5, 85.9) | 85.3 (77.9, 95.3) | 0.059 |
| BMI (kg/m2) | 25.3±3.4 | 26.5±3.9 | 0.258 | 27.5 (25.4, 30.0) | 28.3 (25.6, 30.9) | 0.273 |
| Height (m) | 156±5 | 158±7 | 0.455 | 170±5 | 174±7 | 0.023 |
| Total muscle mass kg) | 13.88 (12.19, 15.18) | 13.98 (13.24, 15.26) | >0.5 | 21.22±1.75 | 21.95±2.51 | 0.234 |
| Arm fat mass (kg) | 3.16 (2.38, 3.62) | 3.21 (2.63, 3.78) | >0.5 | 2.51 (1.76, 2.91) | 2.97 (2.60, 3.49) | 0.008 |
| Leg fat mass (kg) | 9.12 (6.95, 12.01) | 9.25 (7.98, 11.41) | >0.5 | 6.37 (5.27, 7.95) | 7.25 (6.29, 9.73) | 0.042 |
| Arm muscle mass (kg) | 3.36±0.65 | 3.49±0.62 | 0.469 | 5.65 (5.14, 6.32) | 6.19 (5.56, 6.35) | 0.083 |
| Leg muscle mass (kg) | 10.83±1.65 | 10.96±1.62 | >0.5 | 15.80±1.82 | 16.56±2.69 | 0.250 |
| 6MW | 304 ± 129 | 310 ± 108 | >0.5 | 364 (285, 413) | 340 (277, 400) | >0.5 |
| SPPB | 8 (6, 9) | 7 (6, 8.5) | 0.440 | 8 (6, 8) | 8 (6, 9) | 0.220 |
| Grip strength (kg) | 13.69 ± 3.76 | 13.41 ± 2.99 | >0.5 | 24.78 ± 6.61 | 23.29 ± 3.81 | 0.319 |
| QMVC (kg) | 12.20 (7.15, 15.30) | 10.20 (8.70, 14.40) | >0.5 | 17.30 (12.45, 20.88) | 15.40 (13.08, 21.50) | >0.5 |
BMI: body mass index, SARC-F: Strength, assistance with walking, rising from a chair, climbing stairs, and falls questionnaire score, SPPB: Short Physical Performance Battery score: QMVC: Quadriceps Maximal Voluntary contraction. For normally distributed data values are given as mean ± SD and for data that did not show a normal distribution values are median (interquartile range). Body composition measurements were not available for 1 male. QMVC measurements were not available for 1 female and 6 males. 6MW distance was not available for 1 male.