Table 4. Effect of the minor allele of rs2854464 on body composition and strength in females and males at baseline.
| rs2854464 | ||||||
|---|---|---|---|---|---|---|
| female | male | |||||
| AA | AG/GG | P value | AA | AG/GG | P value | |
| n | 27 | 29 | 27 | 25 | ||
| Weight | 62.3±10.9 | 66.0±10.6 | 0.194 | 80.2 (74.2, 86.0) | 85.3 (77.2, 96.0) | 0.107 |
| BMI (kg/m2) | 25.4±3.6 | 26.6±3.8 | 0.286 | 27.7 (25.5, 30.1) | 28.3 (25.5, 31.4) | >0.5 |
| Height (m) | 156 (152, 161) | 155 (153, 161) | >0.5 | 170±5 | 174±7 | 0.017 |
| Total muscle mass (kg) | 13.87 (12.37, 15.23) | 13.98 (13.32, 15.45) | 0.441 | 21.41±1.80 | 21.81±2.56 | >0.5 |
| Arm fat mass (kg) | 3.19 (2.33, 3.56) | 3.21 (2.64, 3.82) | >0.5 | 2.55 (1.82, 2.95) | 2.97 (2.60, 3.46) | 0.023 |
| Leg fat mass (kg) | 9.16 ± 2.82 | 10.05 ± 3.27 | 0.308 | 6.55 (5.31, 8.40) | 7.18 (6.20, 9.58) | 0.158 |
| Arm muscle mass (kg) | 3.42 ± 0.64 | 3.42 ± 0.63 | >0.5 | 5.72 (5.15, 6.42) | 6.18 (5.49, 6.64) | 0.132 |
| Leg muscle mass (kg) | 10.83 ± 1.63 | 10.88 ± 1.68 | >0.5 | 15.85 ± 1.88 | 16.57 ± 2.72 | 0.271 |
| 6MW | 322 (240, 384) | 308 (258, 350) | 0.496 | 372 (293, 414) | 325 (266, 400) | 0.360 |
| SPPB | 8 (6, 10) | 7 (6, 8) | 0.298 | 8 (6, 8) | 8 (6, 9) | >0.5 |
| Grip strength (kg) | 14.4 (11.8, 16.0) | 12.7 (11.3, 16.7) | 0.422 | 24.6 ± 6.3 | 23.4 ± 4.2 | 0.425 |
| QMVC (kg) | 12.4 ± 6.0 | 10.6 ± 4.0 | 0.217 | 15.6 (12.3, 19.9) | 17.4 (13.5, 22.3) | 0.322 |
BMI: body mass index, SARC-F: Strength, assistance with walking, rising from a chair, climbing stairs, and falls questionnaire score, SPPB: Short Physical Performance Battery score: QMVC: Quadriceps Maximal Voluntary contraction. For normally distributed data values are given as mean ± SD and for data that did not show a normal distribution values are median (interquartile range). Body composition measurements were not available for 1 male. QMVC measurements were not available for 1 female and 6 males. 6MW distance was not available for 1 male.