Skip to main content
. 2023 Nov 14;12:RP87147. doi: 10.7554/eLife.87147

Figure 4. Photoreceptor genes important for phototransduction are downregulated in all homeodomain (HD) mutants.

(A) Box plot showing that genes in the detection of light stimulus gene ontology (GO) term were downregulated and affected to various degrees in different adult (P21) HD mutant mouse retinas. (B) Heatmap showing that expression of both cone and rod phototransduction genes were downregulated in adult (P21) HD mutant mouse retinas. Annotation of rod and cone enrichment of each gene is in Supplementary file 1f. See Figure 4—figure supplement 1 for the developmental expression dynamics of these genes.

Figure 4.

Figure 4—figure supplement 1. Developmental expression pattern of phototransduction genes in WT animals.

Figure 4—figure supplement 1.

(A) Parallel coordinates plot showing expression pattern of genes in GO:0009583 during normal postnatal retina development (data from GEO: GSE87064). Row z-score is shown. (B) Heatmap showing expression patterns of phototransduction genes during normal postnatal retina development (data from GEO: GSE87064). Row z-score is shown.