Table 3.
Risk of anastomotic leakage
| CRP on POD 2 | CRP on POD 3 | CRP on POD 4 | Trend in CRP on POD 2 to 3* | Trend in CRP on POD 3 to 4† | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| < 211 mg/L | ≥ 211 mg/L | P-value | < 222 mg/L | ≥ 222 mg/L | P-value | < 190 mg/L | ≥ 190 mg/L | P-value | < 4.65% | ≥ 4.65% | P-value | < − 25.7% | ≥ − 25.7% | P-value | |
| OR | OR | OR | OR | OR | OR | OR | OR | OR | OR | ||||||
| (95% CI) | (95% CI) | (95% CI) | (95% CI) | (95% CI) | (95% CI) | (95% CI) | (95% CI) | (95% CI) | (95% CI) | ||||||
| Crude | 1.00 | 2.21 | < 0.001 | 1.00 | 2.84 | < 0.001 | 1.00 | 3.49 | < 0.001 | 1.00 | 4.59 | < 0.001 | 1.00 | 2.07 | 0.095 |
| (Reference) | (1.49–3.29) | (Reference) | (1.93–4.18) | (Reference) | (2.37–5.15) | (Reference) | (2.29–9.19) | (Reference) | (0.87–4.94) | ||||||
| Adjusted | 1.00 | 2.17 | < 0.001 | 1.00 | 2.65 | < 0.001 | 1.00 | 3.30 | < 0.001 | 1.00 | 3.67 | 0.001 | 1.00 | 2.09 | 0.119 |
| (Reference) | (1.42–3.31) | (Reference) | (1.77–3.99) | (Reference) | (2.21–4.95) | (Reference) | (1.66–8.38) | (Reference) | (0.83–5.74) | ||||||
Multivariable logistic regression models were adjusted for age, sex, body mass index, ASA score, clinical T and N status, neoadjuvant therapy, surgical approach, and type of surgery
CRP C-reactive protein, POD postoperative day, OR odds ratio, CI confidence interval
*Only patients above the cutoff value of CRP 211 mg/L on POD 2 were included
†Only patients above the cutoff value of CRP 222 mg/L on POD 3 were included
Bold numbers indicate statistical significance