Table 4.
Risk of all severe complications (C-D ≥ 3)
| CRP on POD 2 | CRP on POD 3 | CRP on POD 4 | Trend in CRP on POD 2 to 3* | Trend in CRP on POD 3 to 4† | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| < 161 mg/L | ≥ 161 mg/L | P-value | < 208 mg/L | ≥ 208 mg/L | P-value | < 189 mg/L | ≥ 189 mg/L | P-value | < 2.85% | ≥ 2.85% | P-value | < − 13.7% | ≥ − 13.7% | P-value | |
| OR | OR | OR | OR | OR | OR | OR | OR | OR | OR | ||||||
| (95% CI) | (95% CI) | (95% CI) | (95% CI) | (95% CI) | (95% CI) | (95% CI) | (95% CI) | (95% CI) | (95% CI) | ||||||
| Crude | 1.00 | 2.05 | < 0.001 | 1.00 | 3.01 | < 0.001 | 1.00 | 3.37 | < 0.001 | 1.00 | 2.25 | < 0.001 | 1.00 | 2.23 | 0.006 |
| (Reference) | (1.48–2.84) | (Reference) | (2.13–4.26) | (Reference) | (2.36–4.79) | (Reference) | (1.40–3.61) | (Reference) | (1.26–3.95) | ||||||
| Adjusted | 1.00 | 1.58 | < 0.001 | 1.00 | 2.98 | < 0.001 | 1.00 | 3.40 | < 0.001 | 1.00 | 2.30 | 0.002 | 1.00 | 2.54 | 0.004 |
| (Reference) | (1.32–2.61) | (Reference) | (2.08–4.34) | (Reference) | (2.36–4.94) | (Reference) | (1.37–3.89) | (Reference) | (1.35–4.87) | ||||||
Multivariable logistic regression models were adjusted for age, sex, body mass index, ASA score, clinical T and N status, neoadjuvant therapy, surgical approach, and type of surgery
C-D Clavien–Dindo classification, CRP C-reactive protein, POD postoperative day, OR odds ratio, CI confidence interval
*Only patients above the cutoff value of CRP 161 mg/L on POD 2 were included
†Only patients above the cutoff value of CRP 208 mg/L on POD 3 were included
Bold numbers indicate statistical significance