Table 2.

Statistical association of individual histological features with clinical outcomes for the full thickness of the epithelium and basal epithelial layer (n = 75).

	Full epithelium		Full epithelium		Basal epithelial layer		Basal epithelial layer
Event	MT		R		MT		R
	AUROC	p value	AUROC	p value	AUROC	p value	AUROC	p value
Cellularity	0.5075	0.7877	0.5188	0.841	0.5241	0.7824	0.5137	0.6818
Perimeter	0.6118	0.0336*	0.5683	0.1012	not assessed
Nucleus circularity	0.6471	0.0645	0.6903	0.0180*	0.535	0.7659	0.5534	0.6668
Nucleus eccentricity	0.6405	0.0639	0.5687	0.2975	0.5145	0.9563	0.5573	0.2392
Nucleus haematoxylin OD	0.5348	0.8844	0.5553	0.5495	0.5464	0.6162	0.5522	0.5059
Cytoplasm eosin OD	0.5531	0.4115	0.5856	0.1747	0.5559	0.5787	0.5895	0.1915
Nuclear/cell area ratio	0.5428	0.2621	0.5114	0.6103	0.5423	0.3326	0.5353	0.3967

Asterisk denotes statistically significant result (* p ≤ 0.05, ** p ≤ 0.01).

MT malignant transformation, R OED recurrence AUROC area under receiver operating characteristic.