. 2023 Sep 25;129(10):1619–1624. doi: 10.1038/s41416-023-02444-2

Table 3.

Tumor regression grade according to Ryan’s scores.

		Ryan’s score^a				Tot (n.)	p value
		TRG-0	TRG-1	TRG-2	TRG-3
Exploratory cohort	pMMR	21	43	75	9	148	p < 0.0001
Exploratory cohort	dMMR	–	–	2	10	12	p < 0.0001
Validation cohort	pMMR	19	44	72	11	146	p < 0.0001
Validation cohort	dMMR	–	–	3	9	12	p < 0.0001

^aRyan tumor regression (TRG) score: TRG-0 no visible cancer cells (complete response); TRG-1 single cells or small group of cancer cells (near-complete response); TRG-2 residual cancer with evident tumor regression, but more than single cells or rare small group of cancer cells (partial response); TRG-3 extensive residual cancer with no evident tumor regression (poor or no response).