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. 2023 Nov 14;13:19881. doi: 10.1038/s41598-023-47312-4

Table 4.

Cerebrospinal fluid analysis in patients with Lyme neuroborreliosis.

Variables Early LNB
(all patients)
Cranial neuropathies* Encephalitis* Myelitis* Late LNB
Pleocytosis, cellsx106/l, median (IQR); min–max; N 112 (57.75–238.25); 12–867; N = 100

117 (69–260.75);

19–867;

N = 56

400 (93–589); 45–613; N = 9

682.50 (592–0); 592–973;

N = 2

230; 135–305; N = 3
Lymphocytes %, median (IQR); min–max; N 97.5 (92–100); (10–100); N = 98

97 (90–100); 10–100;

N = 55

98 (80.50–100); 65–100; N = 5 51 (10–92); N = 2 90; 21–97; N = 3
Protein, g/l, median (IQR); min–max; N 1.10 (0.70–1.65); 0.33–6.09 1.23 (0.71–1.69); 0.36–6.09; N = 56 1.3 (0.84–4.29); 0.70–6.09; N = 9 3.41; 1.05–5.77; N = 2 3.3; 1.8–6.47; N = 3
Glucose, mmol/l, median (IQR); min–max; N

3.04 (2.60–3.44);

0.40–5.50

3 (2.58–3.50); 0.4–4.38;

N = 55

2.9 (2.21–3.73); 1.60–5.50; N = 9 2.03; 0.4–3.65; N = 2 2.6; 1.88–3.1; N = 3
Intrathecal synthesis of B. burgdorferi s.l. N (%)
 IgM 60/95 (63.2) 34/52 (65.4) 4/9 (44.4) 1/2 (50) 1/3 (33.3)
 IgG 79/98 (77.6) 45/55 (81.8) 8/9 (88.9) 1/2 (50) 3/3 (100)
 Either IgM or IgG, or both 92/100 (92) 52/56 (92.9) 9/9 (100) 2/2 (100) 3/3 (100)

*Patients with early LNB.

LNB Lyme neuroborreliosis, IQR interquartile range.

Normal values: protein (g/l) 0.15–0.45;