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. 2023 Nov 14;7:120. doi: 10.1038/s41698-023-00471-z

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — a GSEA analysis demonstrates a significant enrichment in of KEGG metabolic pathways in MBM versus PCM (left lane) or ECM (right lane). The normalized enrichment score (NES) is indicated by the size of the dot and the -log10 p value (cut off FDR < 0.05) is indicated by the color of the dot. b Heat maps of Spearman rank correlations between NES of OXPHOS, TCA cycle (TCA), and glycolysis (GLYC) determined from ssGSEA and computationally inferred immune cell abundance in PCM, MBM, and ECM. The numbers in each box show the correlation coefficient, where crossed boxes indicate non-significant correlation values (p > 0.05).