Comparison 2. Clonidine versus midazolam.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Number pain‐free in PACU	2	80	Risk Ratio (M‐H, Random, 95% CI)	1.21 [0.61, 2.38]
1.1 Low dose clonidine	1	40	Risk Ratio (M‐H, Random, 95% CI)	0.92 [0.54, 1.56]
1.2 High dose clonidine	1	40	Risk Ratio (M‐H, Random, 95% CI)	1.83 [0.80, 4.18]
2 Nausea and vomiting	3		Risk Ratio (M‐H, Random, 95% CI)	Subtotals only
2.1 Low dose clonidine	1	23	Risk Ratio (M‐H, Random, 95% CI)	0.27 [0.03, 2.51]
2.2 High dose clonidine	3	257	Risk Ratio (M‐H, Random, 95% CI)	0.67 [0.32, 1.40]
3 Postoperative shivering	2		Risk Ratio (M‐H, Fixed, 95% CI)	Subtotals only
3.1 Low dose clonidine	1	23	Risk Ratio (M‐H, Fixed, 95% CI)	0.18 [0.02, 1.44]
3.2 High dose clonidine	2	123	Risk Ratio (M‐H, Fixed, 95% CI)	0.09 [0.01, 0.69]
4 Time to discharge from PACU	2	174	Mean Difference (IV, Random, 95% CI)	‐9.85 [‐19.61, ‐0.09]