Table 4.

Negative binomial regression results: predictors of immune activation and senescence in CD4 and CD8 T cells.

Variable	Immune Activationa Coefficient (SE) b				Immune Senescencea Coefficient (SE) b
	CD4 HLADR+CD38+	CD8 HLADR+CD38+	CD4 PD1+	CD8 PD1+	CD4 CD28-CD57+	CD8 CD28-CD57+	CD4 CD28-CD57+CD38+	CD8 CD28-CD57+CD38+
Intercept	-5.17 (0.61) ***	-4.00 (0.57) ***	-2.42 (0.30) ***	-3.01 (0.32) ***	-5.11 (0.84) ***	-1.76 (0.33) ***	-2.30 (0.71) **	-2.96 (0.50) ***
Gender (Male)	-0.02 (0.19)	-0.04 (0.18)	0.03 (0.09)	0.07 (0.10)	0.18 (0.27)	0.05 (0.11)	0.25 (0.23)	-0.10 (0.16)
Ethnicity (Hispanic)	0.18 (0.21)	0.11 (0.20)	-0.16 (0.11)	-0.09 (0.12)	0.07 (0.31)	0.01 (0.12)	-0.13 (0.26)	-0.01 (0.18)
Race (African American)	0.37 (0.23)	0.16 (0.22)	0.18 (0.12)	-0.01 (0.13)	0.74 (0.33) *	0.21 (0.13)	-0.18 (0.28)	0.18 (0.20)
Race (Other)	0.31 (0.36)	0.03 (0.37)	0.53 (0.20) **	-0.04 (0.22)	1.37 (0.54) *	0.27 (0.23)	-0.08 (0.50)	-0.08 (0.35)
Age	0.01 (0.01)	-0.01 (0.01)	0.01 (0.01) **	0.01 (0.01) *	0.04 (0.01) *	0.01 (0.01)	-0.01 (0.01)	0.01 (0.01)
HIV Infection	0.41 (0.18) *	0.90 (0.17) ***	0.18 (0.09) *	0.23 (0.10) *	0.16 (0.26)	0.12 (0.10)	0.46 (0.22) *	0.50 (0.15) **
Opioid Use	0.19 (0.22)	0.25 (0.21)	0.06 (0.11)	0.46 (0.12) ***	-0.03 (0.32)	0.15 (0.13)	0.89 (0.27) **	1.22 (0.20) ***
Stimulant Use	0.52 (0.20) **	0.90 (0.19) ***	0.24 (0.10) *	0.08 (0.11)	0.77 (0.28) **	0.17 (0.11)	0.06 (0.24)	0.48 (0.17) **
Cannabinoid Use	-0.13 (0.19)	-0.12 (0.18)	-0.08 (0.10)	-0.05 (0.10)	-0.21 (0.27)	0.05 (0.11)	-0.12 (0.23)	-0.29 (0.16)
Alcohol Use	-0.22 (0.22)	0.14 (0.20)	0.01 (0.11)	0.18 (0.12)	-0.39 (0.31)	-0.10 (0.12)	0.10 (0.26)	0.17 (0.19)
Benzodiazepine Use	-0.40 (0.30)	-0.15 (0.26)	-0.14 (0.14)	-0.14 (0.15)	-0.29 (0.41)	0.01 (0.16)	-0.42 (0.34)	0.08 (0.24)
Smoking	-0.12 (0.25)	0.31 (0.25)	-0.31 (0.12) *	-0.002 (0.14)	-1.07 (0.34) **	-0.25 (0.14)	-0.20 (0.30)	-0.18 (0.21)

^an=103 for each regression,

^bp-values: ***p<0.001, **p<0.01, *p<0.05.