Table 1.

General characteristics of the included studies.

Study	Year	Country	Patients, n			Mean age at surgery (years)	Sex		Study design	LOE	Mean follow-up (months)
			Total	SG	CON		M	F
Hoxie et al. (16)	2008	USA	107	35	72	53 (29–78)	23	12	RMCS	III	45 (2–239)
Magnussen et al. (17)	2012	France	44*	22	22	58.1 ± 10.2	7	15	RMCS	III	33.6 (7.2–276)
Watters et al. (18)	2017	USA	144	122	122	58	67	55	RMCS	III	39.6 (24–117.6)
Lizaur-Utrilla et al. (19)	2018	Spain	74	37	37	69.6 ± 7.1 (41–74)	22	15	RMCS	III	73.2 (60–87.6)
Chong et al. (20)	2018	USA	266	64	202	54 ± 9.0 (32–72)	56	45	RMCS	III	10.4 ± 10.0 (0.9–55.2)
James et al. (22)	2019	USA	446†	223†	223	57.2 (31–88)	144	79	RMCS	III	16.7 (2–84)
Anil et al. (21)	2020	USA	464‡	116‡	348‡	55.5 ± 10.1	80	36	RMCS	III	19.7 ± 7.6 (minimum 6)

*Final cohort of patients assessed for clinical evaluation at final follow-up (n = 16);

^†Study group have mixed cohort of TKA performed in previous multi-ligament reconstruction (n = 35) and isolated ACL reconstruction (n = 188);

^‡Complications were assessed only on patients with a minimum of 6 months follow-up: 251 patients in the non-anterior cruciate ligament reconstruction (ACLR) group and 82 patients in the ACLR group.

CON, control; F, female; LOE, level of evidence; M, male; RMCS, retrospective matched cohort study; SG, study group.