TABLE 3.
Preclinical research on Tripterygium wilfordii Hook F.
| Disease | Properties | Related pathways and molecules |
|---|---|---|
| RA | Anti-inflammatory | ROS-NF-κB-NLRP3 |
| Immune regulation | IκB- IKKα/IKKβ-P65 | |
| Alleviate joint damage | TNF、IFN、IL-6、IL-8、 | |
| STAT3-Mtor/Akt-Th17 p38 MAPK/caspase3 | ||
| OPG/RANK/RANKL | ||
| VEGF/FLT1/CCR5 | ||
| SLE | Anti-inflammatory | SYK-MEK-ERK-NF-κB |
| Psoriasis | Anti-inflammatory | IL-6, INF-γ, and IL-22 |
| Immune regulation | DCs-CD4+T/Th17- TNF-α/IL-17A | |
| Crohn’s disease | Anti-inflammatory | NF-κB- TNF-α/IL-6 |
| TNF-α- Foxp3 Tregs- IL-10 | ||
| Multiple sclerosis | Anti-inflammatory | Hsp70- NF-κB/IκB |
| Immune cell regulation |