Figure EV3. The effect of increased consecutive quadruplex sequences and interrupting tracts of poly(dG)₆₀ or poly(dC)₆₀ on replisome stalling.

• A–D
  Quantification of stall intensities from three independent experiments of relevant substrates, as indicated in Fig 2A–D. The 3 kb stalling intensity band was normalised to the intensity of ‘leading strand 2’ in each lane to account for variation in the efficiencies of reactions for each substrate. The mean stalling intensity is plotted with error bars representing the standard error.