Table 4.
Concentrations of JAK3, STAT5, and SOCS3 in HaCaT cell culture exposed to LPS and adalimumab
| Protein | Control | HaCaT with LPS | HaCaT with LPS and adalimumab | ||
|---|---|---|---|---|---|
| H_8 | H_2 | H_8 | H_24 | ||
| JAK3 [pg/ml] | 209.98 ±4.99 | 165.18 ±9.87* | 99.04 ±3.45* | 100.03 ±2.91* | 85.55 ±2.09* |
| SOCS3 [pg/ml] | 143.32 ±3.76 | 102.54 ±2.66* | 80.11 ±1.65* | 23.43 ±2.16* | 20.08 ±0.98* |
| STAT5 [ng/ml] | 8.17 ±1.54 | 8.01 ±1.34 | 6.12 ±0.23* | 5.41 ±0.31* | 3.16 ±0.54* |
SOCS3 – suppressor of cytokine signalling 3, JAK3 – Janus kinase 3, STAT5 – signal transducer and activator of transcription 5, H_2, H_8, H_24 – time of exposure of keratinocytes to LPS or adalimumab,
*
statistically significant difference in comparison with a control (p < 0.05).