Comparison 1. MHRV versus placebo.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Change in morning PEF at 12 months (% predicted)	1		Mean Difference (Fixed, 95% CI)	Totals not selected
2 Change in evening PEF at 12 months (% predicted)	1		Mean Difference (Fixed, 95% CI)	Totals not selected
3 Change in FEV1 at 12 months (% predicted)	1		Mean Difference (Fixed, 95% CI)	Totals not selected
4 Change in rescue medication (puffs/day) after 12 months	1		Mean Difference (Fixed, 95% CI)	Totals not selected
5 Change in ACQ score after 12 months	1		Mean Difference (Fixed, 95% CI)	Totals not selected
6 Change in SGRQ score after 12 months	1		Mean Difference (Fixed, 95% CI)	Totals not selected
7 Exacerbations needing oral steroids	1		Odds Ratio (M‐H, Random, 95% CI)	Totals not selected
8 Exacerbation needing GP visit	1		Odds Ratio (M‐H, Random, 95% CI)	Totals not selected
9 Exacerbation needing GP out of hours	1		Odds Ratio (M‐H, Random, 95% CI)	Totals not selected
10 Exacerbations needing ED visit	1		Odds Ratio (M‐H, Random, 95% CI)	Totals not selected
11 Exacerbations needing hospitalisation	1		Odds Ratio (M‐H, Random, 95% CI)	Totals not selected