Table 1.

The International Consensus Classification of ALL

B-acute lymphoblastic leukemia (B-ALL)

B-ALL with recurrent genetic abnormalities

B-ALL with t(9;22)(q34.1;q11.2)/BCR::ABL1

with lymphoid only involvement

with multilineage involvement

B-ALL with t(v;11q23.3)/KMT2A rearranged

B-ALL with t(12;21)(p13.2;q22.1)/ETV6::RUNX1

B-ALL, hyperdiploid

B-ALL, low hypodiploid

B-ALL, near haploid

B-ALL with t(5;14)(q31.1;q32.3)/IL3::IGH

B-ALL with t(1;19)(q23.3;p13.3)/TCF3::PBX1

B-ALL, BCR::ABL1-like, ABL-1 class rearranged

B-ALL, BCR::ABL1-like, JAK-STAT activated

B-ALL, BCR::ABL1-like, NOS

B-ALL with iAMP21

B-ALL with MYC rearrangement

B-ALL with DUX4 rearrangement

B-ALL with MEF2D rearrangement

B-ALL with ZNF384 rearrangement

B-ALL with NUTM1 rearrangement

B-ALL with HLF rearrangement

B-ALL with UBTF::ATXN7L3/PAN3,CDX2 (“CDX2/UBTF”)

B-ALL with IKZF1 N159Y

B-ALL with PAX5 P80R

Provisional entities (see Table 3):

B-ALL, ETV6::RUNX1-like

B-ALL, with PAX5 alteration

B-ALL, with mutated ZEB2 (p.H1038R)/IGH::CEBPE

B-ALL, ZNF384 rearranged-like

B-ALL, KMT2A rearranged-like

T-acute lymphoblastic leukemia (T-ALL)

Early T-cell precursor ALL, BCL11B-activated

Early T-cell precursor ALL, NOS

T-ALL, NOS

Provisional entities (see Table 4)

Provisional entity: Natural killer (NK) cell ALL