Table 3.

Provisional entities in B-ALL

Subtype	Frequency	Genomics
ETV6::RUNX1-like	<5%, mostly children; worse prognosis than ETV6::RUNX1	Fusions or CNAs in ETS family genes including ETV6, FUS and also IKZF1; some cases harbor germline loss-of-function ETV6 mutations
PAX5 altered (PAX5alt)	10% of children and adults	Various mutations (especially compound heterozygosity for R38;R140), intragenic amplifications, and non-kinase fusions (ETV6 most common); CDKN2A co-mutations common
ZEB2 H1038R/IGH::CEBPE	< 1%	ZEB2 H1038R or IGH::CEBPE; Frequent NRAS mutations (50%), LMO1 upregulation and downregulation of SMAD1 and BMP2
KMT2A-like	<1%	Some with HOXA fusions
ZNF384-like	<1%	Many with alternate ZNF362-r; others unknown