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. 2023 Sep 12;82(12):1516–1526. doi: 10.1136/ard-2023-224482

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© Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

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ContRAst 1 and 2 study design. *Stable oral dose of MTX and ≥5 mg/week folic acid as standard of care. †Otilimab solution in vial/pre-filled syringe. ‡Tofacitinib administered as 5 mg oral capsule. ACR20, 20% improvement in American College of Rheumatology criteria; b/csDMARD, biologic/conventional synthetic disease-modifying antirheumatic drug; C1, contRAst 1; C2, contRAst 2; IR, inadequate response; JAKi, Janus kinase inhibitor; LTE, long-term extension; MTX, methotrexate; RA, rheumatoid arthritis, SC, subcutaneous; W, week.