Table 3.
Long-term outcome data for MTC patients with codon 618 vs 634 mutations.
| C618R (n=31) |
C634R/T/Y (n=15) |
P value | |
|---|---|---|---|
| Surveillance duration (years), Mean ± SD, range | 12.5 ± 12.6, 0-31 (n=31) |
12.3 ± 14.0, 0-42 (n=13) |
0.974 |
| Disease status one year post-surgery | |||
| Persistent disease (n,%) | 9/20 (45.0%) | 5/12 (41.7%) | 0.854 |
| Biochemical (n,%) | 5/8 (62.5%) | 4/5 (80.0%) | |
| Structural (n,%) | 3/8 (37.5%) | 1/5 (20.0%) | |
| Mortality (n,%) | 1/21 (4.8%) | 0 | |
| Disease status at final follow up | |||
| Persistent / recurrent disease (n,%) | 11/26 (42.3%) | 6/13 (46.2%) | 0.819 |
| Biochemical (n,%) | 6/11 (54.5%) | 5/6 (83.3%) | |
| Structural / both (n,%) | 5/11 (45.4%) | 1/6 (16.7%) | |
| Overall mortality (n,%) | 2/31 (6.5%) | 2/15 (13.3%) | 0.587 |