Table 4.
Factors associated with MTC persistence/recurrence in the Cys618Arg cohort.
| Persistence/recurrence 1 year post-operatively | P value | Persistence/recurrence at last visit | P value | |||
|---|---|---|---|---|---|---|
| Yes | No | Yes | No | |||
| Age at surgery (years), Mean ± SD, range | 29.3 ± 9.9, 15-50 (n=9) |
26.7 ± 12.6, 8-49 (n=11) |
0.619 | 28.8 ± 9.0, 11-50 (n=11) |
23.8 ± 12.3, 8-49 (n=15) |
0.263 |
| Tumor size at surgery (mm), Mean ± SD, range | 17.8 ± 5.2, 11-40 (n=5) |
7.6 ± 4.9, 2-15 (n=9) |
0.003 | 16.0 ± 6.4, 5-40 (n=6) |
7.0 ± 4.5, 2-15 (n=12) |
0.003 |
| Gender | ||||||
| Male | 4/9 (44.4%) |
5/9 (55.6%) | 5/12 (41.7%) | 7/12 (58.3%) | ||
| Female | 5/11 (45.5%) | 6/11 (54.5%) | 1.000 | 6/14 (42.9%) | 8/14 (57.1%) | 0.951 |
| Lymph node dissection performed | ||||||
| Yes | 5/9 (55.6%) |
4/9 (44.4%) | 7/12 (58.3%) | 5/12 (41.7%) | ||
| No | 3/10 (30.0%) | 7/10 (70.0%) |
0.370 | 3/11 (27.3%) | 8/11 (72.7%) | 0.214 |
| Lymph node metastases | ||||||
| Yes | 5/5 (100%) | 0/5 (0%) | 6/6 (100%) | 0/6 (0%) | ||
| No | 0/4 (0%) | 4/4 (100%) | 0.008 | 1/6 (16.7%) | 5/6 (83.3%) | 0.015 |
| Parental origin of gene | ||||||
| Maternal | 2/7 (28.6%) |
5/7 (71.4%) | 2/7 (28.6%) | 5/7 (71.4%) | ||
| Paternal | 7/12 (58.3%) | 5/12 (41.7%) |
0.350 | 8/18 (44.4%) | 10/18 (55.6%) | 0.659 |
| Generation | ||||||
| Early | 5/8 (62.5%) |
3/8 (37.5%) | 6/10 (60%) | 4/10 (40%) | ||
| Late | 4/11 (36.4%) | 7/11 (63.6%) |
0.370 | 4/15 (26.7%) | 11/15 (73.3%) | 0.122 |
The bold values indicate results with statistically significant differences between groups.