CENTRAL (CRS)	Cochrane ENT Register (CRS)	MEDLINE (Ovid)
1 MESH DESCRIPTOR Otitis Media with Effusion EXPLODE ALL AND CENTRAL:TARGET 2 ("otitis media" adj6 effusion):AB,EH,KW,KY,MC,MH,TI,TO AND CENTRAL:TARGET 3 (OME):TI,TO AND CENTRAL:TARGET 4 (Secretory otitis media):AB,EH,KW,KY,MC,MH,TI,TO AND CENTRAL:TARGET 5 (Serous otitis media):AB,EH,KW,KY,MC,MH,TI,TO AND CENTRAL:TARGET 6 (Middle‐ear effusion):AB,EH,KW,KY,MC,MH,TI,TO AND CENTRAL:TARGET 7 (glue ear):AB,EH,KW,KY,MC,MH,TI,TO AND CENTRAL:TARGET 8 (middle‐ear perfusion):AB,EH,KW,KY,MC,MH,TI,TO AND CENTRAL:TARGET 9 MESH DESCRIPTOR Otitis Media AND CENTRAL:TARGET 10 (otitis media):TI,TO AND CENTRAL:TARGET 11 #9 OR #10 AND CENTRAL:TARGET 12 (((effusion or Recurrent or persistent or serous or secretory or perfusion) adj3 otitis)):AB,EH,KW,KY,MC,MH,TI,TO AND CENTRAL:TARGET 13 #11 AND #12 AND CENTRAL:TARGET 14 #1 OR #2 OR #3 OR #4 OR #5 OR #6 OR #7 OR #8 OR #13 AND CENTRAL:TARGET	1 MESH DESCRIPTOR Otitis Media EXPLODE ALL AND INREGISTER 2 ("otitis media" OR OME OR "glue ear" OR middle‐ear effusion OR middle‐ear perfusion):AB,EH,KW,KY,MC,MH,TI,TO AND INREGISTER 3 #1 OR #2 4 (effusion or Recurrent or persistent or serous or secretory or perfusion):AB,EH,KW,KY,MC,MH,TI,TO AND INREGISTER 5 #3 AND #4	1 exp Otitis Media with Effusion/ 2 ("otitis media" adj6 effusion).ab,ti. 3 OME.ti. 4 Secretory otitis media.ab,ti. 5 Serous otitis media.ab,ti. 6 Middle‐ear effusion.ab,ti. 7 Glue ear.ab,ti. 8 middle‐ear perfusion.ab,ti. 9 Otitis Media/ 10 otitis media.ti. 11 9 or 10 12 ((effusion or Recurrent or persistent or serous or secretory or perfusion) adj3 otitis).ab,ti. 13 11 and 12 14 1 or 2 or 3 or 4 or 5 or 6 or 7 or 8 or 13 15 randomized controlled trial.pt. 16 controlled clinical trial.pt. 17 randomized.ab. 18 placebo.ab. 19 drug therapy.fs. 20 randomly.ab. 21 trial.ab. 22 groups.ab. 23 15 or 16 or 17 or 18 or 19 or 20 or 21 or 22 24 exp animals/ not humans.sh. 25 23 not 24 26 14 and 25
Embase (Ovid)	Web of Science (Web of knowledge)	Trial registries (CRS)
1 exp secretory otitis media/ 2 ("otitis media" adj6 effusion).ab,ti. 3 OME.ti. 4 Secretory otitis media.ab,ti. 5 Serous otitis media.ab,ti. 6 Middle‐ear effusion.ab,ti. 7 glue ear.ab,ti. 8 middle‐ear perfusion.ab,ti. 9 otitis media/ 10 otitis media.ti. 11 9 or 10 12 ((effusion or Recurrent or persistent or serous or secretory or perfusion) adj3 otitis).ab,ti. 13 11 and 12 14 1 or 2 or 4 or 5 or 6 or 7 or 8 or 13 15 (random* or factorial* or placebo* or assign* or allocat* or crossover*).tw. 16 (control* adj group*).tw. 17 (trial* and (control* or comparative)).tw. 18 ((blind* or mask*) and (single or double or triple or treble)).tw. 19 (treatment adj arm*).tw. 20 (control* adj group*).tw. 21 (phase adj (III or three)).tw. 22 (versus or vs).tw. 23 rct.tw. 24 crossover procedure/ 25 double blind procedure/ 26 single blind procedure/ 27 randomization/ 28 placebo/ 29 exp clinical trial/ 30 parallel design/ 31 Latin square design/ 32 15 or 16 or 17 or 18 or 19 or 20 or 21 or 22 or 23 or 24 or 25 or 26 or 27 or 28 or 29 or 30 or 31 33 exp ANIMAL/ or exp NONHUMAN/ or exp ANIMAL EXPERIMENT/ or exp ANIMAL MODEL/ 34 exp human/ 35 33 not 34 36 32 not 35 37 14 and 36	11 #10 AND #9 Indexes=SCI‐EXPANDED, CPCI‐S Timespan=All years 10 #8 OR #7 OR #6 OR #5 OR #4 OR #3 OR #2 OR #1 Indexes=SCI‐EXPANDED, CPCI‐S Timespan=All years 9 TS=(randomised OR randomized OR randomisation OR randomisation OR placebo* OR (random* AND (allocat* OR assign*) ) OR (blind* AND (single OR double OR treble OR triple) )) Indexes=SCI‐EXPANDED, CPCI‐S Timespan=All years 8 (TI=(otitis media) ) AND TS=((effusion or Recurrent or persistent or serous or secretory or perfusion) NEAR/3 otitis) Indexes=SCI‐EXPANDED, CPCI‐S Timespan=All years 7 TOPIC: ((middle‐ear perfusion) ) Indexes=SCI‐EXPANDED, CPCI‐S Timespan=All years 6 TOPIC: ((glue ear) ) Indexes=SCI‐EXPANDED, CPCI‐S Timespan=All years 5 TOPIC: ((Middle‐ear effusion) ) Indexes=SCI‐EXPANDED, CPCI‐S Timespan=All years 4 TOPIC: ((Serous otitis media) ) Indexes=SCI‐EXPANDED, CPCI‐S Timespan=All years 3 TOPIC: ((Secretory otitis media) ) Indexes=SCI‐EXPANDED, CPCI‐S Timespan=All years 2 TITLE: (OME) Indexes=SCI‐EXPANDED, CPCI‐S Timespan=All years 1 TOPIC: ("otitis media" NEAR/6 effusion) Indexes=SCI‐EXPANDED, CPCI‐S Timespan=All years	1 ("otitis media" OR OME OR "glue ear" OR middle‐ear effusion OR middle‐ear perfusion):AB,EH,KW,KY,MC,MH,TI,TO AND CENTRAL:TARGET 2 (effusion or Recurrent or persistent or serous or secretory or perfusion):AB,EH,KW,KY,MC,MH,TI,TO AND CENTRAL:TARGET 3 #1 AND #2 4 http*:SO AND CENTRAL:TARGET 5 (NCT0* or ACTRN* or ChiCTR* or DRKS* or EUCTR* or eudract* or IRCT* or ISRCTN* or JapicCTI* or JPRN* or NTR0* or NTR1* or NTR2* or NTR3* or NTR4* or NTR5* or NTR6* or NTR7* or NTR8* or NTR9* or SRCTN* or UMIN0*):AU AND CENTRAL:TARGET 6 #4 OR #5 7 #3 AND #6
ClinicalTrials.gov	ICTRP
(EXPAND[Concept] "otitis media" OR EXPAND[Concept] "glue ear" OR middle‐ear ) AND (effusion OR Recurrent OR persistent OR serous OR secretory OR perfusion ) | Interventional Studies	(otitis media AND effusion) OR glue ear OR middle‐ear effusion OR middle‐ear perfusion