Table 2.

Comparison of the reproductive outcomes of the CC + letrozole and CC-alone groups

Outcome	Letrozole + CC	Clomiphene citrate	Absolute difference between groups (95% CI)a	Rate ratio in combination group (95% CI)b	P-values
Primary outcome
Ovulation, n (%)
Intention to treat analysis†	39 (78)	35 (70)	8.0 (-9.1 to 24.6)	1.11 (0.88 to 1.41)	0.494
Per-protocol analysis‡	37 (77)	33 (70)	6.9 (-10.7 to 24.0)	1.10 (0.86 to 1.40)	0.447
Secondary outcomes
Pregnancy, n(%)
Conception	3 (6.3)	2 (4.3)	2.0 (-8.8 to 13.0)	1.47 (0.26 to 8.40)	1.000
Clinical pregnancy	1	2	NA*	NA*	NA*
Live birth	1	1	NA*	NA*	NA*
Pregnancy loss	2	1	NA*	NA*	NA*
Fecundity among those who ovulated
Conception	3/37	2/33	2.0 (-12.5 to 15.9)	1.34 (0.24 to 7.52)	1.000
Clinical pregnancy	1/37	2/33	NA*	NA*	NA*
Live birth	1//37	1/33	NA*	NA*	NA*

^† Letrozole + CC, n = 50; CC, n = 50

^‡ Letrozole + CC, n = 48; CC, n = 47

^a Differences are presented as percentages

^b Differences are presented as ratio

NA* not applicable due to small sample