Table 4.
Drug tolerability and adverse events compared between the CC + letrozole and CC alone groups
| Event | Letrozole + CC group (n = 48) |
Clomiphene citrate group (n = 47) |
P-values |
|---|---|---|---|
| Anaphylaxis, n | 0 | 0 | – |
| Minor side effects, n (%) | 24 (50) | 22 (46.8) | 0.916 |
| Side-effects acceptable | 24 (100) | 22 (100) | – |
| Reported side-effects, n (%) | |||
| Headache | 3 (12.5) | 1 (4.5) | 0.609 |
| Dizziness | 2 (8.3) | 4 (18.2) | 0.405 |
| Hot flush | 5 (20.8) | 1 (4.5) | 0.190 |
| Abdominal bloating | 7 (29.2) | 6 (27.3) | 1.000 |
| Abdominal pain including cramping | 3 (12.5) | 2 (9.1) | 1.000 |
| Nausea | 2 (8.3) | 1 (4.5) | 1.000 |
| Mood changes | 4 (16.7) | 3 (13.6) | 1.000 |
| Fatigue | 5 (20.8) | 3 (13.6) | 0.702 |
| Breast discomfort | 5 (20.8) | 5 (22.7) | 1.000 |
| Diarrhea | 5 (20.8) | 2 (9.1) | 0.418 |
| Night sweats | 4 (16.7) | 1 (4.5) | 0.349 |
| Sleep disturbance | 3 (12.5) | 5 (22.7) | 0.451 |
| Adverse events of ongoing pregnancy, n (%) | |||
| Spontaneous complete abortion | 1 (2.08) | 1 (2.13) | NA* |
| Early pregnancy loss | 1 (2.08) | 1 (2.13) | NA* |
NA* not applicable due to small sample