Table 2.
Frequency of genetic alleles potentially linked to malaria resistance to anti-folate drugs in the DRC
| Alleles | n* | m* | Median % of mutants (IQR) |
|---|---|---|---|
| PfDHPS alleles | |||
| I431V | 1588 | 14 | 1.4 (0.9) |
| S436A | 2165 | 297 | 7.4 (13.9) |
| A437G | 2103 | 1821 | 88.0 (33.6) |
| K540E | 3518 | 1373 | 38.9 (47.7) |
| A581G | 3076 | 431 | 10.7 (17.7) |
| A613S | 1684 | 10 | 0.1 (0.5) |
| PfDHFR alleles | |||
| N51I | 2324 | 2260 | 97.9 (25.0) |
| C59R | 2324 | 1937 | 79.1 (0.0625) |
| S108N | 2324 | 2291 | 99.5 (11.9) |
| I164L | 2927 | 2 | < 0.1 (3.94) |
(*) n: no. of genotyped isolates; m: no. of detected mutants