Table 3.
Results of ROC curve analyses that test the proposed relatively optimal WHtR cut-offs of 0.50 and 0.46 to discriminate those with ≥ 2 cardiometabolic risk factors, stratified by country
| Country | Age (years) | No. of subjects | Cut-offs | IDF criteria | NCEP criteria | ||||
|---|---|---|---|---|---|---|---|---|---|
| AUC (95% CI) | Sensitivity | Specificity | AUC (95% CI) | Sensitivity | Specificity | ||||
| Brazil | 15–17 | 441 | 0.46 | 0.680 (0.574–0.785) | 0.562 | 0.797 | 0.565 (0.491–0.640) | 0.338 | 0.793 |
| 0.50 | 0.626 (0.534–0.718) | 0.312 | 0.939 | 0.574 (0.517–0.632) | 0.203 | 0.946 | |||
| China | 6–11 | 1416 | 0.46 | 0.731 (0.655–0.808) | 0.880 | 0.582 | 0.652 (0.597–0.707) | 0.704 | 0.599 |
| 0.50 | 0.702 (0.597–0.807) | 0.640 | 0.764 | 0.661 (0.604–0.718) | 0.539 | 0.783 | |||
| Greece | 8–17 | 439 | 0.46 | 0.624 (0.559–0.689) | 0.923 | 0.325 | 0.624 (0.564–0.683) | 0.908 | 0.340 |
| 0.50 | 0.626 (0.531–0.722) | 0.718 | 0.535 | 0.647 (0.569–0.726) | 0.738 | 0.566 | |||
| Iran | 6–18 | 8171 | 0.46 | 0.587 (0.565–0.609) | 0.425 | 0.749 | 0.578 (0.561–0.595) | 0.393 | 0.763 |
| 0.50 | 0.578 (0.560–0.597) | 0.261 | 0.895 | 0.565 (0.552–0.579) | 0.225 | 0.906 | |||
| Italy | 10–13 | 570 | 0.46 | 0.605 (0.527–0.683) | 0.938 | 0.273 | 0.595 (0.534–0.657) | 0.909 | 0.281 |
| 0.50 | 0.663 (0.547–0.780) | 0.812 | 0.514 | 0.651 (0.567–0.734) | 0.773 | 0.529 | |||
| Korea | 6–18 | 7769 | 0.46 | 0.668 (0.644–0.693) | 0.572 | 0.765 | 0.653 (0.633–0.673) | 0.527 | 0.778 |
| 0.50 | 0.607 (0.585–0.629) | 0.317 | 0.897 | 0.612 (0.594–0.629) | 0.314 | 0.910 | |||
| South Africa | 10–16 | 1271 | 0.46 | 0.635 (0.575–0.695) | 0.514 | 0.756 | 0.608 (0.562–0.655) | 0.448 | 0.769 |
| 0.50 | 0.588 (0.534–0.642) | 0.305 | 0.871 | 0.583 (0.542–0.623) | 0.281 | 0.884 | |||
| Spain | 6–13 | 631 | 0.46 | 0.684 (0.618–0.749) | 0.952 | 0.487 | 0.665 (0.605–0.724) | 0.897 | 0.433 |
| 0.50 | 0.730 (0.648–0.813) | 0.905 | 0.556 | 0.731 (0.669–0.793) | 0.879 | 0.583 | |||
| UK | 10–11 | 783 | 0.46 | 0.801 (0.784–0.818) | 1 | 0.602 | 0.655 (0.555–0.754) | 0.710 | 0.610 |
| 0.50 | 0.894 (0.880–0.908) | 1 | 0.788 | 0.664 (0.561–0.768) | 0.553 | 0.795 | |||
| USA | 12–17 | 3114 | 0.46 | 0.658 (0.623–0.694) | 0.826 | 0.491 | 0.665 (0.635–0.695) | 0.826 | 0.504 |
| 0.50 | 0.670 (0.629–0.711) | 0.662 | 0.678 | 0.691 (0.657–0.725) | 0.687 | 0.695 | |||
Abbreviations AUC Area under the curve, CI Confidence interval, IDF International Diabetes Federation, NCEP National Cholesterol Education Program, P Percentile, ROC Receiver operator characteristic, UK United Kingdom, USA United States of America, WHtR Waist-to-height ratio