Table 4.
Combined protective genotypes of the two independent SNPs and OS of HBV-related HCC in the combined dataset
| NPGsa | Combined dataset (N = 866) | Multivariable analysis | ||
|---|---|---|---|---|
| All | Death (%) | HR (95% CI) | P b | |
| 0 | 161 | 91 (56.5) | 1.00 | |
| 1 | 473 | 240 (50.7) | 0.76 (0.59-0.97) | 0.026 |
| 2 | 232 | 88 (37.9) | 0.51 (0.38-0.69) | <0.001 |
| Trend test | <0.001 | |||
| 0 | 161 | 91 (56.5) | 1.00 | |
| 1-2 | 705 | 328 (46.5) | 0.67 (0.53-0.85) | <0.001 |
Abbreviations: SNPs: single nucleotide polymorphisms; OS: overall survival; HBV: hepatitis B virus; HCC: hepatocellular carcinoma; HR: hazards ratio; 95% CI: 95% confidence interval; NPGs: number of protective genotypes.
a Protective genotypes were SLC2A9 rs28643326 TC/CC and SLC5A10 rs2472711 GT/TT.
b Multivariate Cox proportional hazards regression analysis was adjusted for age, sex, smoking status, drinking status, AFP level, cirrhosis, embolus, and BCLC stage.