Table 5.
Stratified analysis of combined protective genotypes with OS of HBV-related HCC
| Characteristics | NPG 0 | NPGs 1-2 | Multivariable analysis | ||||
|---|---|---|---|---|---|---|---|
| All | Death (%) | All | Death (%) | HR (95% CI) | P a | P inter b | |
| Age (year) | 0.061 | ||||||
| ≤47 | 81 | 55 (67.9) | 353 | 178 (50.4) | 0.57 (0.42-0.77) | <0.001 | |
| >47 | 80 | 36 (45.0) | 352 | 150 (42.6) | 0.85 (0.58-1.22) | 0.373 | |
| Sex | 0.299 | ||||||
| Female | 20 | 12 (60.0) | 86 | 30 (34.9) | 0.53 (0.26-1.09) | 0.083 | |
| Male | 141 | 79 (56.0) | 619 | 298 (48.1) | 0.67 (0.52-0.87) | 0.002 | |
| Smoking status | 0.724 | ||||||
| No | 109 | 64 (58.7) | 436 | 204 (46.8) | 0.72 (0.54-0.96) | 0.025 | |
| Yes | 52 | 27 (51.9) | 269 | 124 (46.1) | 0.57 (0.37-0.88) | 0.011 | |
| Drinking status | 0.499 | ||||||
| No | 125 | 71 (56.8) | 489 | 221 (45.2) | 0.66 (0.50-0.86) | 0.003 | |
| Yes | 36 | 20 (55.6) | 216 | 107 (49.5) | 0.68 (0.41-1.11) | 0.122 | |
| AFP level (ng/ml) | 0.060 | ||||||
| ≤400 | 94 | 45 (47.9) | 428 | 187 (43.7) | 0.76 (0.55-1.06) | 0.100 | |
| >400 | 67 | 46 (68.7) | 277 | 141 (50.9) | 0.58 (0.41-0.81) | 0.002 | |
| Cirrhosis | 0.424 | ||||||
| No | 72 | 38 (52.8) | 318 | 146 (45.9) | 0.66 (0.45-0.95) | 0.026 | |
| Yes | 89 | 53 (59.6) | 387 | 182 (47.0) | 0.70 (0.51-0.95) | 0.023 | |
| Embolus | 0.831 | ||||||
| No | 124 | 62 (50.0) | 512 | 198 (38.7) | 0.67 (0.50-0.90) | 0.008 | |
| Yes | 37 | 29 (78.4) | 193 | 130 (67.4) | 0.68 (0.44-1.04) | 0.076 | |
| BCLC stage | 0.658 | ||||||
| 0/A | 82 | 33 (40.2) | 345 | 113 (32.8) | 0.66 (0.45-0.98) | 0.042 | |
| B/C | 79 | 58 (73.4) | 360 | 215 (59.7) | 0.67 (0.50-0.90) | 0.008 | |
Abbreviations: OS: overall survival; HBV: hepatitis B virus; HCC: hepatocellular carcinoma; NPGs: number of protective genotypes; HR: hazards ratio; 95% CI: 95% confidence interval; Pinter: P-value for interaction.
a Multivariate Cox proportional hazards regression analysis was adjusted for age, sex, smoking status, drinking status, AFP level, cirrhosis, embolus, and BCLC stage.
b P-value for multiplicative interaction analysis between variables and NPG.