Table 1.
The exome-wide association study analysis of IgAN patients and control groups.
| GENE | CHR | POSITION | MARKER | BONF | A1 | F_A | F_U | A2 | CHISQ | p | OR (95% CI) | SE |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Additive | ||||||||||||
| PRAG1 | 8 | 8,176,387 | rs143409664 | 1.808 × 10–15 | CGGGGCG | 0.4571 | 0.07692 | C | 179.8 | 5.464 × 10–41 | 10.11 (6.834–14.94) | 0.1996 |
| ZNF787 | 19 | 56,599,437 | rs5828672 | 2.926 × 10–14 | C | 0.4929 | 0.07849 | CTCG | 205.8 | 1.13 × 10–46 | 11.41 (7.731–16.84) | 0.1986 |
| TRBV5-4 | 7 | 142,168,890 | rs767448033 | 3.146 × 10–12 | T | 0.3571 | 0.07849 | C | 103.3 | 2.906 × 10–24 | 6.522 (4.365–9.745) | 0.2048 |
| TENM3 | 4 | 183,370,244 | rs35591339 | 5.646 × 10–12 | A | 0.5071 | 0.08399 | AGCG | 205.3 | 1.485 × 10–46 | 11.22 (7.629–16.51) | 0.1969 |
| PIM1 | 6 | 37,138,023 | rs1300416314 | 2.207 × 10–11 | G | 0.4286 | 0.1148 | GGCA | 99.66 | 1.81 × 10–23 | 5.784 (3.969–8.429) | 0.1921 |
| CYTH2 | 19 | 48,985,178 | rs34527214 | 7.812 × 10–10 | TA | 0.5357 | 0.1546 | T | 117.9 | 1.814 × 10–27 | 6.308 (4.378–9.089) | 0.1863 |
| MISP3 | 19 | 14,184,713 | rs35666756 | 8.00 × 10–9 | CG | 0.3429 | 0.09105 | C | 78.01 | 1.028 × 10–18 | 5.208 (3.499–7.753) | 0.2029 |
| EOMES | 3 | 27,763,427 | rs368178421 | 3.243 × 10–8 | GCGGCGC | 0.3623 | 0.1009 | G | 76.89 | 1.805 × 10–18 | 5.06 (3.418–7.491) | 0.2001 |
| FBXO27 | 19 | 39,505,111 | rs4803184 | 3.255 × 10–8 | G | 0.4786 | 0.1389 | A | 101.9 | 5.818 × 10–24 | 5.688 (3.938–8.216) | 0.1876 |
| SH3PXD2A | 10 | 105,428,453 | rs10533306 | 3.656 × 10–8 | C | 0.4714 | 0.1852 | CAG | 61.51 | 4.41 × 10–15 | 3.923 (2.735–5.627) | 0.184 |
| Dominant | ||||||||||||
| PRAG1 | 8 | 8,176,387 | rs143409664 | 1.654 × 10–15 | CGGGGCG | 0.4571 | 0.07692 | C | 179.8 | 5.464 × 10–41 | 10.11 (6.834–14.94) | 0.1996 |
| TRBV5-4 | 7 | 142,168,890 | rs767448033 | 3.146 × 10–12 | T | 0.3571 | 0.07849 | C | 103.3 | 2.906 × 10–24 | 6.522 (4.365–9.745) | 0.2048 |
| ZNF787 | 19 | 56,599,437 | rs5828672 | 3.25 × 10–11 | C | 0.4929 | 0.07849 | CTCG | 205.8 | 1.13 × 10–46 | 11.41 (7.731–16.84) | 0.1986 |
| PIM1 | 6 | 37,138,023 | rs1300416314 | 1.187 × 10–10 | G | 0.4286 | 0.1148 | GGCA | 99.66 | 1.81 × 10–23 | 5.784 (3.969–8.429) | 0.1921 |
| MISP3 | 19 | 14,184,713 | rs35666756 | 3.523 × 10–9 | CG | 0.3429 | 0.09105 | C | 78.01 | 1.028 × 10–18 | 5.208 (3.499–7.753) | 0.2029 |
| EOMES | 3 | 27,763,427 | rs368178421 | 3.964 × 10–9 | GCGGCGC | 0.3623 | 0.1009 | G | 76.89 | 1.805 × 10–18 | 5.06 (3.418–7.491) | 0.2001 |
| SREBF1 | 17 | 17,740,164 | rs60282872 | 2.629 × 10–8 | G | 0.2643 | 0.08477 | GC | 44.17 | 3.013 × 10–11 | 3.878 (2.537–5.928) | 0.2165 |
| PRTN3 | 19 | 843,692 | rs2301879 | 3.49 × 10–8 | G | 0.2929 | 0.08948 | A | 53.45 | 2.646 × 10–13 | 4.214 (2.792–6.361) | 0.2101 |
| AMACR | 5 | 34,008,206 | rs3217251 | 6.688 × 10–8 | C | 0.2857 | 0.08085 | CCGGCGCCACGCCCCCAGCCG | 58.24 | 2.322 × 10–14 | 4.548 (2.993–6.91) | 0.2135 |
| CHRNA3 | 15 | 78,913,067 | rs751352647 | 1.363 × 10–7 | A | 0.4214 | 0.1546 | ACAG | 60.56 | 7.149 × 10–15 | 3.982 (2.755–5.755) | 0.1879 |
| Recessive | ||||||||||||
| UBR3 | 2 | 170,871,976 | rs13028230 | 1.545 × 10–9 | A | 0.5429 | 0.2951 | G | 35.59 | 2.431 × 10–9 | 2.836 (1.991–4.039) | 0.1804 |
| PKD1L1 | 7 | 47,835,116 | rs2348459 | 2.031 × 10–9 | T | 0.5571 | 0.2363 | C | 66.2 | 4.077 × 10–16 | 4.067 (2.844–5.815) | 0.1825 |
| DNAH11 | 7 | 21,639,818 | rs6461586 | 2.649 × 10–9 | T | 0.3643 | 0.1586 | C | 36.34 | 1.657 × 10–9 | 3.041 (2.089–4.427) | 0.1916 |
| CIAO2A | 15 | 64,381,148 | rs16947748 | 2.861 × 10–9 | G | 0.5786 | 0.2841 | A | 50.83 | 1.01 × 10–12 | 3.459 (2.421–4.942) | 0.1821 |
| TRMT9B | 8 | 12,870,438 | rs2466264 | 6.754 × 10–9 | C | 0.6714 | 0.3265 | G | 65.07 | 7.224 × 10–16 | 4.215 (2.907–6.112) | 0.1896 |
| MDN1 | 6 | 90,400,292 | rs954638 | 9.888 × 10–9 | C | 0.4929 | 0.179 | T | 74.9 | 4.943 × 10–18 | 4.458 (3.108–6.397) | 0.1842 |
| PIEZO2 | 18 | 10,757,868 | rs7242408 | 1.003 × 10–8 | A | 0.5071 | 0.2276 | G | 51.83 | 6.039 × 10–13 | 3.491 (2.445–4.986) | 0.1818 |
| OR10G6 | 11 | 123,865,086 | rs7944434 | 1.053 × 10–8 | A | 0.4571 | 0.1743 | C | 62.56 | 2.583 × 10–15 | 3.991 (2.777–5.735) | 0.185 |
| PWP2 | 21 | 45,547,563 | rs2242954 | 1.658 × 10–8 | G | 0.4 | 0.1931 | C | 32.15 | 1.427 × 10–8 | 2.786 (1.933–4.016) | 0.1865 |
| BAIAP2 | 17 | 79,084,072 | rs4072588 | 2.268 × 10–8 | T | 0.5214 | 0.2339 | G | 53.88 | 2.132 × 10–13 | 3.568 (2.499–5.095) | 0.1817 |
Notes: CHR—chromosome, POSITION—base pair based on the human reference genome GRCh37, A1—minor allele, F_A—frequency of A1 allele in patients, F_U—frequency of A1 allele in controls, A2—major allele, CHISQ—basic allelic test chi-square (1df), p—p-value for CHISQ, OR (95% CI)—odds ratio and confidence interval for odds ratio, SE—standard error, BONF—Bonferroni single-step adjusted p-values.