Table A3.
The genetic markers with r2 > 0.7, that were significant in at least one logistic regression model.
| Gene | MARKER | CHR | BP | A1 | F_A | F_U | A2 | p | OR (95% CI) | BONF ADD | BONF DOM | BONF REC | R2 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| LGALS8 | rs2244809 | 1 | 236,702,117 | T | 0.55 | 0.2849 | G | 1.274 × 10–10 | 3.067 (2.152–4.372) | 0.01239 | ns | 2.732 × 10–5 | 0.9507 (rs1041937); 0.865722 (rs2244808); 0.660795 (rs11807205) |
| rs2244808 | 236,702,153 | G | 0.6 | 0.3163 | A | 2.016 × 10–11 | 3.242 (2.266–4.638) | 0.007593 | ns | 1.236 × 10−4 | 0.865722 (rs2244809); 0.822342 (rs1041937); 0.759458 (rs11807205) | ||
| rs1041937 | 236,702,210 | A | 0.4857 | 0.2857 | G | 1.08 × 10–6 | 2.361 (1.659–3.361) | ns | ns | 0.01863 | 0.822342 (rs2244808); 0.9507 (rs2244809); 0.668001 (rs11807205) |
||
| rs11807205 | 236,702,475 | A | 0.6286 | 0.3501 | G | 1.106 × 10–10 | 3.142 (2.188–4.511) | 0.02077 | ns | 8.544 × 10−4 | 0.759458 (rs2244808); 0.660795 (rs2244809); 0.668001 (rs1041937) | ||
| rs2254823 | 236,711,297 | A | 0.55 | 0.2849 | G | 1.274 × 10–10 | 3.067 (2.266–4.638) | 0.007593 | ns | 1.236 × 10−4 | 0.96159 | ||
| rs15701 | 236,711,323 | T | 0.6 | 0.3163 | A | 2.016 × 10–11 | 3.242 (1.855–3.761) | ns | ns | 0.02441 | |||
| COX7A2L | rs12613284 | 2 | 42,562,787 | C | 0.5071 | 0.3462 | G | 1.685 × 10−4 | 1.944 (1.368 –2.761) | ns | ns | 0.043 | 0.991318 |
| rs10194796 | 42,562,821 | A | 0.5071 | 0.3454 | C | 1.555 × 10−4 | 1.95 (1.373–2.77) | ns | ns | 0.03463 | |||
| DNAH5 | rs6554808 | 5 | 13,735,147 | C | 0.6 | 0.3666 | A | 7.614 × 10−8 | 2.592 (1.814–3.703) | ns | ns | 3.987 × 10−4 | 0.85481 |
| rs2401811 | 13,737,700 | A | 0.5714 | 0.3611 | G | 1.157 × 10–6 | 2.359 (1.656–3.361) | ns | ns | 0.006805 | |||
| MYL10-CUX1 | rs740202 | 7 | 101,280,652 | T | 0.5929 | 0.4074 | G | 2.52 × 10–5 | 2.118 (1.485–3.022) | ns | ns | 0.006267 | 0.997391 |
| rs1636453 | 101,281,232 | A | 0.5929 | 0.4082 | T | 2.737 × 10–5 | 2.111 (1.48–3.012) | ns | ns | 0.007734 | |||
| OR4K3 | rs5807006 | 14 | 20,336,681 | A | 0.5429 | 0.2504 | AG | 2.464 × 10–13 | 3.555 (2.491–5.074) | ns | ns | 0.007604 | 0.734943 |
| rs1892239 | 14 | 20,336,733 | A | 0.45 | 0.2206 | G | 1.905 × 10–9 | 2.891 (2.021–4.137) | ns | ns | 0.00812 | ||
| OR4E1 | rs7144135 | 14 | 22,138,328 | G | 0.45 | 0.1915 | A | 1.905 × 10–12 | 3.454 (2.407–4.956) | ns | ns | 9.527 × 10−4 | 0.996356 |
| rs970025 | 14 | 221,384,37 | A | 0.45 | 0.1907 | G | 1.538 × 10–12 | 3.471 (2.419–4.981) | ns | ns | 6.463 × 10−4 | ||
| SYNE2 | rs10138253 | 14 | 64,520,416 | G | 0.3786 | 0.1586 | A | 1.301 × 10–10 | 3.233 (2.226–4.695) | ns | ns | 9.15 × 10–6 | 0.870958 |
| rs1255972 | 14 | 64,532,107 | A | 0.3429 | 0.1633 | G | 1.621 × 10–7 | 2.674 (1.83–3.907) | ns | ns | 0.001809 | ||
| FBN1 | rs11070641 | 15 | 48,701,029 | C | 0.4 | 0.2221 | T | 2.882 × 10–6 | 2.335 (1.624–3.356) | ns | ns | 6.838 × 10−4 | 0.871057 |
| rs4775760 | 15 | 48,701,612 | A | 0.4357 | 0.2386 | C | 4.227 × 10–7 | 2.464 (1.722–3.525) | ns | ns | 8.167 × 10−4 | ||
| LOC400499 | rs9932266 | 16 | 11,594,747 | G | 0.5214 | 0.3053 | T | 2.285 × 10–7 | 2.479 (1.743–3.526) | ns | ns | 2.209 × 10–5 | 0.860027 |
| rs4781105 | 16 | 11,596,040 | C | 0.5071 | 0.3148 | G | 4.606 × 10–6 | 2.24 (1.576–3.185) | ns | ns | 1.181 × 10−4 | ||
| CRISPLD2-ZDHHC7 | rs2646133 | 16 | 84,953,145 | A | 0.4929 | 0.3383 | G | 2.826 × 10−4 | 1.901 (1.338–2.700) | ns | ns | 0.03866 | 0.739664 (rs2646130); 0.988681 (rs2646132); 0.988681 (rs60944306) |
| rs2646132 | 16 | 84,953,232 | C | 0.4929 | 0.3367 | T | 2.417 × 10−4 | 1.914 (1.347–2.719) | ns | ns | 0.031 | 1 (rs60944306); 0.988681 (rs2646133); 0.747952 (rs2646130) | |
| rs60944306 | 16 | 84,953,233 | A | 0.4929 | 0.3367 | C | 2.417 × 10−4 | 1.914 (1.347–2.719) | ns | ns | 0.031 | 0.747952 (rs2646130); 1 (rs2646132); 0.988681 (rs2646133) |
|
| rs2646130 | 16 | 84,953,351 | G | 0.4571 | 0.2645 | A | 1.59 × 10–6 | 2.341 (1.642–3.339) | ns | ns | 0.002581 | 0.747952 (rs2646132); 0.739664 (rs2646133); 0.747952 (rs60944306) | |
| KRBA2 | rs1695213 | 17 | 8,279,324 | T | 0.6 | 0.3344 | C | 5.215× 10–10 | 2.986 (2.088–4.27) | ns | ns | 1.967 × 10–7 | 0.907883 |
| RPL26 | rs422679 | 17 | 8,285,398 | T | 0.6214 | 0.3579 | C | 1.166 × 10–9 | 2.945 (2.054–4.222) | ns | ns | 4.826 × 10–6 | |
| CEP192 | rs9783903 | 18 | 13,000,210 | A | 0.5429 | 0.3595 | G | 2.159 × 10–5 | 2.116 (1.488–3.007) | ns | ns | 0.01879 | 0.976515 |
| CEP192 | rs1787008 | 18 | 13,058,318 | A | 0.5357 | 0.354 | G | 2.418 × 10–5 | 2.106 (1.482–2.992) | ns | ns | 0.02432 |
Notes: CHR—chromosome, BP—base pair based on the human reference genome GRCh37, A1—minor allele, F_A—frequency of A1 allele in patients, F_U—frequency of A1 allele in controls, A2—major allele, p—p-value for CHISQ, OR (95% CI)—odds ratio and confidence interval for odds ratio, BONF—Bonferroni single-step adjusted p-values (ADD—additive, DOM—dominant and REC—recessive logistic models), R2—intervariant allele count squared correlations. ns—not significant.