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Mechanisms of resistance to FLT3 inhibitors. (A): Scheme of FLT3 kinase and occurring on-target mutations responsible for the emergence of FLT3i resistance. (B): Off-target mutations found to confer resistance to FLT3 inhibition. (C): Bone marrow microenvironment. Affected by treatment with FLT3i, stromal cells can secrete increased amounts of FLT3 ligands and upregulate CYP3A4, leading to rapid degradation of FLT3i. Created with BioRender.com (accessed on 17 August 2023).
