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. 2023 Oct 25;13(21):3307. doi: 10.3390/diagnostics13213307

Table 2.

Clinical criteria of anaphylaxis (adapted from reference: [42]).

Anaphylaxis Is Highly Likely When Any One of the Following Three Criteria is Fulfilled
Criterion 1

Acute onset of an illness (minutes to several hours) with involvement of the skin, mucosal tissue, or both (e.g., generalized hives, itching, or flushing, swollen lips-tongue-uvula)
AND at least one of the following:

  1. Respiratory compromise (e.g., dyspnea, wheeze-bronchospasm, stridor, reduced peak flow, hypoxia)

  2. Cardiovascular compromise (e.g., hypotension, syncope, collapse, incontinence)

 Criterion 2

Two or more of the following that occur rapidly after exposure to a likely allergen for that patient (minutes to several hours):

  1. Involvement of the skin or mucosal tissue

  2. Respiratory compromise

  3. Cardiovascular compromise

  4. Persistent gastrointestinal symptoms (e.g., crampy abdominal pain, vomiting, diarrhea)

 Criterion 3

* Hypotension after exposure to known allergen for that patient (minutes to several hours)

* Low blood pressure (BP) is defined as systolic BP less than 90 mm Hg. or a decrease greater than 30% from that person’s baseline, or in Infants and children under 10 y: systolic BP less than 70 mm Hg + (2 × age in years).