Abbreviation	Definition
AAV	Adeno-associated viral vector.
AAV1	Adeno-associated viral vector serotype 1.
AAV9	Adeno-associated viral vector serotype 9.
AD	Alzheimer’s disease.
ALS	Amyotrophic lateral sclerosis.
ALSP	Adult-onset leukoencephalopathy with axonal spheroids and pigmented glia.
Aβ	Amyloid-β.
BBB	Blood–brain barrier.
bvFTD	Behavioral variant frontotemporal dementia.
CNS	Central nervous system.
CSF	Cerebrospinal fluid.
CTSD	Cathepsin D.
ERK/p90RSK	Extracellular-signal-regulated kinase/90 kiladalton ribosomal s6 kinase.
FTD	Frontotemporal dementia.
FTD-GRN	Frontotemporal dementia caused by progranulin gene mutation.
FTLD	Frontotemporal lobar degeneration.
FUS	Fused in sarcoma.
GCase	β -glucocerebrosidase.
GRN	Progranulin gene.
iMG	iPSC microglia.
iPSC	Induced pluripotent stem cells.
LATE	Limbic-predominant age-related transactivation response deoxyribonucleic acid binding protein 43 encephalopathy.
LOF	Loss of function.
LRP1	Low-density lipoprotein receptor-related protein.
M6PR	Mannose 6-phosphate receptor.
MCI	Mild cognitive impairment.
MS	Multiple sclerosis.
MS4A	Membrane-spanning 4-domains subfamily A.
NCL	Neuronal ceroid lipofuscinosis.
NFT	Neurofibrillary tangles.
nfvPPA	Non-fluent variant primary progressive aphasia.
PD	Parkinson’s disease.
PET	Positron emission tomography.
PGRN	Progranulin.
PI3K/Akt	Phosphoinositide 3-kinase/protein kinase B.
PPA	Primary progressive aphasia.
PSAP	Prosaposin.
ROS	Reactive oxygen species.
SLPI	Secretory leukocyte peptidase inhibitor.
SOD1	Superoxide dismutase type 1.
sPLA2-IIA	Type IIA secreted phospholipase A2.
svPPA	Semantic variant primary progressive aphasia.
TDP-43	Transactivation response deoxyribonucleic acid binding protein 43.
TFEB	Transcription factor EB.
TNF	Tumor necrosis factor.
TNF-α	Tumor necrosis factor alpha.
TNFR1	Tumor necrosis factor receptor 1.
TNFR2	Tumor necrosis factor receptor 2.
Tregs	Regulatory T cells.
sTREM2	Soluble triggering receptor expressed on myeloid cells 2.
TREM2	Triggering receptor expressed on myeloid cells 2.
Vps10p	Vacuolar protein sorting 10 protein.
WBC	White blood cell.