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. 2023 Nov 5;12(21):2579. doi: 10.3390/cells12212579

Figure 11.

Figure 11

Structure and functional domain map of variants in CTNNA1 (Catenin alpha-1). Secondary structures are derived from Alphafold data (https://alphafold.ebi.ac.uk/entry/P35221 (accessed on 27 October 2023).) [68,69]. Pathogenic and likely pathogenic variants are indicated for those linked to FEVR (red circles), patterned macular dystrophy (red circles with black outlines), and those linked to non-retinal conditions including cancers (black circles). The bottom row * indicates the location of nonsense (stop codon) variants. Exploration of additional non-pathogenic variants can be found in the UniProt database: https://www.uniprot.org/uniprotkb/P35221 (accessed on 27 October 2023).