Table 5.

Mixed linear model for recessive inheritance model. Relationship between the subjects’ BMI at baseline with those at T6 and T12 and its association with SNPs.

			p-Value
CD36 rs1984112 A>G	GG	AA+AG	Genotype a	Time b	Interaction c
BMI
Baseline	29.7 (28.2–31.3)	33.0 (28.6–37.9)	0.438	0.119	0.781
T6	29.3 (28.0–30.6)	35.1 (27.8–38.0)
T12	29.1 (27.8–30.4)	31.8 (26.1–36.1)
CD36 rs1761667 G>A	AA	GG+GA
BMI
Baseline	28.0 (27.3–28.7)	35.9 (31.2–38.0)	0.014	0.001	0.831
T6	27.6 (26.4–28.4)	35.9 (30.6–38.0)
T12	26.1 (25.6–27.9)	34.9 (30.0–36.9)
BMAL1 rs7950226 G>A	AA	GG+GA
BMI
Baseline	34.8 (26.9–44.2)	31.9 (28.5–36.7)	0.400	<0.001	0.877
T6	40.3 (28.0–45.9)	32.7 (27.8–36.5)
T12	32.3 (26.7–41.6)	30.4 (26.1–36.0)
CLOCK rs1801260 A>G	GG	AA+AG
BMI
Baseline	41.1 (27.6–41.3)	31.9 (28.5–36.7)	0.362	<0.001	0.123
T6	40.3 (27.3–40.8)	32.7 (28.0–36.5)
T12	38.6 (36.9–40.4)	30.2 (27.0–35.5)
CLOCK rs4864548 G>A	AA	GG+GA
BMI
Baseline	37.9 (37.9–37.9)	31.6 (28.2–36.7)	0.462	0.049	0.699
T6	36.5 (36.5–36.5)	32.7 (27.9–37.6)
T12	36.0 (36.0–36.0)	30.2 (26.1–36.1)
CLOCK rs3736544 G>A	AA	GG+GA
BMI
Baseline	36.6 (31.9–42.0)	31.2 (28.2–37.9)	0.129	0.078	0.363
T6	37.0 (31.9–42.0)	31.6 (28.0–36.5)
T12	36.1 (27.9–46.5)	30.2 (26.0–35.6)

Data are expressed as median and interquartile range (IQR). Statistically significant values are given in bold. ^a Groups, for each variable, the differences have been tested between Genotypes over time. ^b Time, for each variable, the differences have been tested between baseline, T6, and T12 of the two Genotypes. ^c Probability that the effects of nutritional intervention are greater in one distinct group (interaction Time × Genotype).