Table 3.
Changes in glycemic and lipid parameters before and after intervention with the probiotic or placebo (mean (SD)).
| Probiotics (n = 46) | Placebo (n = 45) | P | |||||
|---|---|---|---|---|---|---|---|
| Baseline | 3 Months | 6 Months | Baseline | 3 Months | 6 Months | ||
| HbA1c (%) | 7.24 (0.49) |
6.82 (0.39) | 6.51 (0.44) | 7.32 (0.52) | 7.19 (0.42) | 7.18 (0.45) | <0.001 |
| Change at 3 months | −0.42 (0.27) | −0.12 (0.32) | |||||
| Change at 6 months | −0.73 (0.42) | −0.14 (0.46) | |||||
| FBG (mmol/L) | 7.55 (1.22) |
6.70 (0.85) | 6.16 (0.83) | 7.70 (1.42) | 7.35 (1.13) | 7.42 (1.42) | <0.001 |
| Change at 3 months | −0.85 (0.95) | −0.35 (0.88) | |||||
| Change at 6 months | −1.39 (1.08) | −0.28 (0.96) | |||||
| TC (mmol/L) | 3.87 (0.76) |
3.71 (0.69) | 3.59 (0.65) | 4.00 (0.79) | 3.95 (0.80) | 4.01 (0.82) | 0.012 |
| Change at 3 months | −0.16 (0.19) | −0.05 (0.42) | |||||
| Change at 6 months | −0.28 (0.27) | 0.01 (0.50) | |||||
| Trig (mmol/L) | 1.43 (0.51) |
1.37 (0.46) | 1.34 (0.46) | 1.51 (0.43) | 1.51 (0.45) | 1.51 (0.46) | NS |
| Change at 3 months | −0.07 (0.09) | −0.01 (0.19) | |||||
| Change at 6 months | −0.09 (0.13) | 0.00 (0.25) | |||||
| HDL-C (mg/dL) | 1.13 (0.30) |
1.15 (0.29) | 1.16 (0.28) | 1.11 (0.28) | 1.10 (0.27) | 1.10 (0.28) | NS |
| Change at 3 months | 0.01 (0.04) | −0.01 (0.08) | |||||
| Change at 6 months | 0.02 (0.07) | −0.02 (0.13) | |||||
| LDL-C (mg/dL) | 2.08 (0.57) |
2.01 (0.56) | 2.00 (0.56) | 2.24 (0.75) | 2.18 (0.73) | 2.22 (0.71) | NS |
| Change at 3 months | −0.07 (0.13) | −0.07 (0.28) | |||||
| Change at 6 months | −0.08 (0.19) | −0.03 (0.30) | |||||
P: Comparison between groups by the two-factor mixed repeated-measure ANOVA adjusted for change in WC at 6 months. HbA1c: glycated hemoglobin; FBG: fasting blood glucose; TC: total cholesterol; Trig: triglycerides, HDL-C: high density lipoprotein cholesterol; LDL-C: low density lipoprotein cholesterol.