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. 2023 Oct 26;12(21):2526. doi: 10.3390/cells12212526

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© 2023 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Comparisons of averaged calcium transients in DCM patients vs. control hiPSC-CMs. Features of calcium transients computed using the Calcium Transient Analysis application in OriginPro 2022. Comparisons were made between hiPSC-CMs derived from a female healthy control (HID041004), male DCM patient (HID041020), and female DCM patient (HID041021). Features investigated were (A) area under the curve, (B) transient duration, (C) time between peaks, (D) time to 50% baseline, (E) time to 90% baseline, (F) time to peak, (G) decay tau, (H) upstroke velocity, (I) transient amplitude, and (J) transient frequency. Multiple comparisons were made using Bonferroni correction. n = 29–33 cells from four independent replicates. * p < 0.05, ** p < 0.01, *** p < 0.001.