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. 2023 Oct 24;24(21):15541. doi: 10.3390/ijms242115541

Table 1.

Stabilities of [99mTc]Tc-DT1 (reference), [99mTc]Tc-DT10, [99mTc]Tc-DT11 and [99mTc]Tc-DT12 in peripheral mouse blood 5 min pi without treatment (controls), or treated with Entresto®, or Lis, or their combination (Entresto® + Lis).

[99mTc]Tc-DT1 1 [99mTc]Tc-DT10 [99mTc]Tc-DT11 [99mTc]Tc-DT12
Control 1.81 ± 0.77 (n = 4) 5.09 ± 0.89 (3) 56.56 ± 5.19 (3) 35.65 ± 5.00 (3)
Entresto® 5.46 ± 3.86 (n = 5) 5.15 ± 1.58 (3) 76.98 ± 3.31 (3) 58.69 ± 7.17 (3)
Lis 18.77 ± 2.54 (n = 3) 37.14 ±6.49 (3) 66.89 ± 1.24 (3) 42.63 ± 2.79 (3)
Entresto® + Lis 63.80 ± 7.51 (n = 3) 68.02 ± 3.01 (3) 86.33 ± 1.94 (3) 73.98 ± 4.93 (3)

1 Metabolic stability results for [99mTc]Tc-DT1 have been adapted from [26,27]; data represent the mean percentage of intact radioligand ± sd; number of experiments are shown in parentheses.