Table 4.
Biodistribution of [99mTc]Tc-DT12 in SCID mice bearing AsPC-1 xenografts at 4 h (block, controls and Entresto® + Lis treated) and 24 h pi (controls and Entresto® + Lis treated); data are expressed as %IA/g and represent average values ± sd, n = 4.
| Organs/Tissues | [99mTc]Tc-DT12 (%IA/g) | ||||
|---|---|---|---|---|---|
| 4 h | 24 h | ||||
| Block | Controls | Entresto® + Lis | Controls | Entresto® + Lis | |
| Blood | 0.06 ± 0.02 | 0.05 ± 0.01 | 0.06 ± 0.01 | 0.05 ± 0.01 | 0.07 ± 0.02 |
| Liver | 0.79 ± 0.38 | 0.26 ± 0.04 | 1.04 ± 0.31 | 0.11 ± 0.00 | 0.41 ± 0.11 |
| Heart | 0.05 ± 0.02 | 0.05 ± 0.01 | 0.09 ± 0.02 | 0.05 ± 0.04 | 0.06 ± 0.02 |
| Kidneys | 3.11 ± 1.29 | 2.43 ± 0.51 | 6.92 ± 2.55 | 0.68 ± 0.10 | 0.83 ± 0.20 |
| Stomach | 0.28 ± 0.17 | 0.19 ± 0.05 | 0.36 ± 0.06 | 0.08 ± 0.01 | 0.14 ± 0.07 |
| Intestines | 1.41 ± 1.04 | 1.12 ± 0.17 | 2.12 ± 0.62 | 0.40 ± 0.03 | 0.55 ± 0.09 |
| Spleen | 1.01 ± 0.68 | 0.28 ± 0.02 | 2.23 ± 0.81 | 0.20 ± 0.03 | 0.97 ± 0.30 |
| Muscle | 0.02 ± 0.02 | 0.03 ± 0.00 | 0.06 ± 0.02 | 0.03 ± 0.01 | 0.04 ± 0.01 |
| Lungs | 0.35 ± 0.12 | 0.12 ± 0.00 | 0.65 ± 0.15 | 0.08 ± 0.01 | 0.26 ± 0.02 |
| Pancreas | 0.08 ± 0.04 | 0.06 ± 0.00 | 0.12 ± 0.02 | 0.05 ± 0.01 | 0.06 ± 0.01 |
| AsPC-1 Tumor | 0.56 ± 0.18 | 3.63 ± 0.42 | 4.48 ± 1.23 | 1.74 ± 0.20 | 2.47 ± 0.57 |