Table 3.
Comparison of pulmonary function profiles at the completion of chemotherapy and 1 year post-chemotherapy.
| Reduced Bleomycin (n = 32) |
Standard Bleomycin (n = 7) |
p-Value | ||
|---|---|---|---|---|
| At the completion of chemotherapy | FVC | 88 (67–121) | 81 (55–105) | 0.23 |
| FEV1 | 89.5 (66–126) | 88 (53–112) | 0.56 | |
| FEV1/FVC | 1 (0.8–1.3) | 0.9 (0.9–1) | 0.21 | |
| DLCO | 61 (1–78) | 68 (46–81) | 0.20 | |
| One year post-chemotherapy | FVC | 83 (72–105) | 75.5 (74–77) | 0.30 |
| FEV1 | 84 (63–102) | 83.5 (81–86) | 0.93 | |
| FEV1/FVC | 1 (0.8–1.2) | 0.9 (0.9–1) | 0.14 | |
| DLCO | 76 (50–99) | 80 (80–80) | 0.66 | |
|
Cycles of chemotherapy ≤ 4
(n = 17) |
Cycles of chemotherapy > 4
(n = 22) |
p-value | ||
| At the completion of chemotherapy | FVC | 97 (55–121) | 84 (63–103) | <0.01 * |
| FEV1 | 100.5 (53–126) | 84.5 (66–104) | <0.01 * | |
| FEV1/FVC | 1 (0.9–1.1) | 1 (0.8–1.3) | 0.67 | |
| DLCO | 62.5 (1–81) | 61 (43–77) | 0.39 | |
| One year post-chemotherapy | FVC | 83 (72–99) | 80.5 (73–105) | 1.00 |
| FEV1 | 86 (63–102) | 80 (64–100) | 0.60 | |
| FEV1/FVC | 1 (0.9–1.1) | 1 (0.8–1.2) | 0.32 | |
| DLCO | 80 (74–99) | 74 (50–87) | 0.06 |
DLCO, diffusion capacity of the lung for carbon monoxide; FEV1, forced expiratory volume in one second; FVC, forced vital capacity. Data are presented as median (range), p-value is calculated using Wilcoxon rank sum test. * statistically significant.