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. 2023 Oct 29;24(21):15718. doi: 10.3390/ijms242115718

Figure 5.

Figure 5

Quantitation of SARS-CoV-2 virus particles in the lungs of treated ACE2-transgenic mice. Mice were intranasally challenged with 2.5 × 104 PFU or 2.5 × 102 PFU SARS-CoV-2 (UF-1) and then treated with the vehicle control (saline), CM398 (sigma-2 receptor-specific ligand), AZ66 (sigma-1/sigma-2 receptor ligand), or diphenhydramine (sigma receptor ligand) combined with lactoferrin. The 50% tissue culture infectious dose (TCID50) was calculated based on lungs harvested 48 h after infection. An “ns” indicates non-statistically significant differences between treatment and placebo groups. Circles represent individual animals.