Table 6.
Voiding LUTS severity and SNP genotypes in men and women.
| Variables | V-IPSS Score in Men | Allele Positivity p Value |
V-IPSS in Women | Allele Positivity p Value |
|||
|---|---|---|---|---|---|---|---|
| Mild/ Moderate <17, n (%) |
Severe ≥17, n (%) |
Mild/ Moderate <17, n (%) |
Severe ≥17, n (%) |
||||
| rs2052129 (c.691G>T) |
GG | 17 (44.7) | 0 | 0.019 | 22 (43.1) | 0 | 0.262 |
| GT-TT | 21 (55.3) | 8 (100.0) | 29 (56.9) | 3 (100.0) | |||
| rs10156191 (p.Thr16Met) |
CC | 14 (36.8) | 0 | 0.085 | 20 (39.2) | 0 | 0.287 |
| CT-TT | 24 (63.2) | 8 (100.0) | 31 (60.8) | 3 (100.0) | |||
| rs2052129 rs10156191 |
No | 18 (47.4) | 0 | 0.015 | 24 (47.1) | 0 | 0.245 |
| Yes | 20 (52.6) | 8 (100.0) | 27 (52.9) | 3 (100.0) | |||
| SNPs | <4 SNPs | 26 (68.4) | 4 (50.0) | 0.421 | 39 (76.5) | 0 | 0.018 |
| 4 SNPs | 12 (31.6) | 4 (50.0) | 12 (23.5) | 3 (100.0) | |||
| Homozygosity | No | 33 (86.8) | 6 (75.0) | 0.597 | 47 (92.2) | 1 (33.3) | 0.030 |
| Yes | 5 (13.2) | 2 (25.0) | 4 (7.8) | 2 (66.7) | |||
Allele positivity compares the presence of the minor allele (either in heterozygosity or homozygosity) related to reduced DAO activity vs. the absence of the minor allele; significance level: chi-square test or Fisher’s exact test.