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. 2023 Nov 5;12(21):2578. doi: 10.3390/cells12212578

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© 2023 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

circRNA-driven circRNA–miRNA–mRNA regulatory network in IHF. circRNAs are indicated as diamonds, miRNAs as ovals, and mRNAs as rounded rectangles; green or red colors indicate down- or up-regulation in IHF, respectively. (A) The network is driven by down-regulated circHIPK3. (B) The network is driven by the up-regulated circRNAs; the inner circle is constituted by mRNAs targeted by multiple miRNAs, and the outer circle displays single miRNA-mRNA interactions (for details on mRNAs in the network, please refer to Supplementary Table S6). (C) The top 15 KEGG terms of the identified interacting mRNAs are represented by a lollipop graph and ordered by FDR enrichment. The size of the lollipop indicates the number of genes, and colors indicate the statistical significance (red for lower FDR, blue for higher FDR).