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. 2005 Mar 15;3(4):e101. doi: 10.1371/journal.pbio.0030101

Figure 7. Fasting-Induced Hepatic Steatosis Develops in PGC-1α−/− Mice.

Figure 7

(A) The photograph depicts the development of a pale liver in PGC-1α−/− mice subjected to a 24-h fast.

(B) Oil red O staining of histologic sections of liver taken from PGC-1α−/− mice under fed and 24 h fasted conditions. The red staining indicates neutral lipid.

(C) Representative electron micrographs of the liver from PGC-1α+/+ and PGC-1α−/− mice following a 24-h fast. The droplets are indicative of neutral lipid accumulation.

(D) Mean liver TAG levels in PGC-1α+/+ (n = 5) and PGC-1α−/− (n = 5) mice under fed and 24-h fasted conditions. * p < 0.05.