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. 2023 Nov 15;3(11):2312–2330. doi: 10.1158/2767-9764.CRC-23-0140

FIGURE 2.

FIGURE 2

Recurrently mutated genes in Hodgkin lymphoma. The frequency and type of mutations affecting genes mutated in 3 or more patients in our cohort are shown in each row. Genes determined to be significantly mutated using MuSiC and/or dN/dScv (FDR < 0.05) are highlighted (SMG = significantly mutated gene). The open SMG shape indicates that a gene was determined to be an SMG only when HL-513 was excluded from the statistical analysis. The filled SMG shape indicates a gene that was determined to be an SMG only when HL-513 was included in the statistical analysis. The darkest SMG shape indicates that a gene was determined to be an SMG in all analyses (including and excluding HL-513). The bar graph on the right summarizes the frequency of mutations for that gene across the entire cohort. For genes with multiple mutations in a single patient, only one mutation type is shown, prioritized by the order listed in the legend.