Table 2.
List of prior pathways and supplement genes
| Dataset | Pathway | Original | Expanded | Supplement genes |
|---|---|---|---|---|
| BRCA | ERK signaling | 18 | 22 | AGPAT2, BAMBI, DGAT2, LINC01235 |
| PI3K signaling | 15 | 15 | – | |
| WNT signaling | 46 | 46 | – | |
| NOTCH signaling | 14 | 22 | LOC110384692, C4A, HLF, SNHG5, ASCL1, ORM2, IFIT2, THBS1 | |
| Nuclear receptor signaling | 5 | 5 | – | |
| Cell cycle | 6 | 17 | IBSP, HEY1, TNN, H2BC4, MTRNR2L1, CGA, TFPI2, TTYH1, ASAH1, PEBP4, TTC36 | |
| Transcription | 9 | 11 | MMP12, MSI1 | |
| THCA | ERK signaling | 12 | 12 | – |
| WNT signaling | 5 | 10 | STC1, APOD, EEF1A2, ND4L, SCX | |
| Transcription | 11 | 11 | – | |
| LGG | ERK signaling | 19 | 20 | H1-2 |
| PI3K signaling | 13 | 13 | – | |
| Calcium signaling | 15 | 15 | – | |
| Cell cycle | 13 | 25 | REM1, C1QL4, MTND4P12, GRB2, RNU4-2, LYVE1, TMEM132E, PCDHB2, ERBB3, H1-2, PCDHGB6, MFAP4 | |
| Transcription | 9 | 10 | H1-2 |