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. 2004 Nov 16;7(1):R47–R56. doi: 10.1186/ar1449

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Copyright © 2004 Giles et al., licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is cited.

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Sequence alignment of the expressed variable light chainregion (V_L) and variable heavy chainregion (V_H), using DNAplot software in VBASE. (a) Sequences of expressed V_λregions compared with gene 2a2. (b) Sequences of expressed V_Hregions compared with genes 1-03 (IS4) and 3–23 (B3). The D_Hregions could not be matched to germline genes. Arginine residues altered by site-directed mutagenesis to serine residues in IS4V_Hcomplementarity determining region (CDR) 3 are underlined. Amino acids are numbered according to Kabat. Dots inserted to facilitate the alignment. Dashes indicate homology with the corresponding germline sequence. FR, framework region.