Table 2.
Summary of logistic regressions for predicting membership of CD subtype on the basis of genotype or allele carrier classification for Model 1 (healthy control used as reference) and for Model 2 (within schizophrenia group only, cognitively spared schizophrenic used as reference). Significant results are highlighted in bold.
| SNP (Risk Allele Carrier) | Model Significance | Predictor | ||||||
|---|---|---|---|---|---|---|---|---|
| Pseudo R2 (Cox and Snell) | B Value | Standard Error | p Value | (95% CI) | Exp (B) | |||
| rs3144 (genotype) | Model 1 (reference category = HC) | Predicting CS subtype: | ||||||
| all | χ2 = 9.143, d.f. = 4, p = 0.058 | 0.028 | −0.177 | 0.324 | 0.583 | (0.444–1.579) | 0.837 | |
| male | χ2 = 13.389, d.f. = 4, p = 0.010 | 0.059 | −0.123 | 0.396 | 0.756 | (0.407–1.923) | 0.884 | |
| female | χ2 = 2.320, d.f. = 4, p = 0.677 | 0.022 | −0.285 | 0.561 | 0.611 | (0.251–2.256) | 0.752 | |
| Predicting CD subtype: | ||||||||
| 0.028 | 0.651 | 0.328 | 0.047 | (1.008–3.648) | 1.917 | |||
| 0.059 | 0.806 | 0.381 | 0.034 | (1.062–4.725) | 2.24 | |||
| 0.022 | 0.071 | 0.687 | 0.917 | (0.280–4.126) | 1.074 | |||
| Model 2 (reference category = CS type) | Predicting CD subtype | |||||||
| all | χ2 = 6.257, d.f. = 2, p = 0.044 | 0.047 | 0.828 | 0.404 | 0.040 | (1.038–5.050) | 2.289 | |
| male | χ2 = 9.944, d.f. = 2, p = 0.007 | 0.098 | 0.930 | 0.476 | 0.051 | (0.997–6.438) | 2.533 | |
| female | χ2 = 1.822, d.f. = 2, p = 0.402 | 0.051 | 0.357 | 0.802 | 0.656 | (0.297–6.877) | 1.429 | |
| rs3144 (minor allele carrier) |
Model 1 (reference category = HC) | Predicting CS subtype: | ||||||
| all | χ2 = 3.823, d.f. = 2, p = 0.148 | 0.012 | 0.101 | 0.284 | 0.723 | (0.634–1.930) | 1.106 | |
| male | χ2 = 3.659, d.f. = 2, p = 0.160 | 0.017 | 0.277 | 0.345 | 0.421 | (0.672–2.593) | 1.32 | |
| female | χ2 = 0.983, d.f. = 2, p = 0.612 | 0.009 | −0.296 | 0.51 | 0.561 | (0.274–2.021) | 0.744 | |
| Predicting CD subtype: | ||||||||
| 0.012 | 0.596 | 0.312 | 0.056 | (0.985–3.342) | 1.815 | |||
| 0.017 | 0.678 | 0.367 | 0.064 | (0.960–4.043) | 1.97 | |||
| 0.009 | 0.397 | 0.6 | 0.437 | (0.459–4.821) | 1.487 | |||
| Model 2 (reference category = CS type) | Predicting CD subtype | |||||||
| all | χ2 = 1.833, d.f. = 1, p = 0.176 | 0.014 | 0.495 | 0.368 | 0.178 | (0.798–3.375) | 1.641 | |
| male | χ2 = 0.862, d.f. = 1, p = 0.353 | 0.009 | 0.401 | 0.433 | 0.355 | (0.639–3.490) | 1.493 | |
| female | χ2 = 0.982, d.f. = 1, p = 0.322 | 0.028 | 0.693 | 0.707 | 0.327 | (0.500–7.997) | 2.000 | |
Abbreviations: CD, cognitive deficits; CS, cognitively spared; HC, healthy control; SNP, single nucleotide polymorphism.