Table 4.
Rs3144 SNP in the Lingo-1 3’-UTR and its minor allelic and genotypic frequencies and tests of allelic association in the tested cohort. The table below provides information on the allelic frequencies (column a), allele carriers (column b, meaning minor allelic carriers (CC and TC) vs. TT, and genotypic frequencies (column c: three genotypes analysed independently).
| a MAF (%) | Allelic Association | b MCF (%) | Allele Carrier Association | c MGF (%) | Genotypic Association | Odds Ratio (OR) | 95% CI | p | ||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| (HC:SZ only) | (HC:SZ only) | (HC:SZ only) | ||||||||||||||||||||
| HC | SZ | CS | CD | χ2 | p | HC | SZ | CS | CD | χ2 | p | HC | SZ | CS | CD | χ2 | p | |||||
| Rs 3144 |
all | 35.64 | 43.31 | 42.03 | 42.74 | 4.28 | 0.03 | 56.12 | 65.49 | 57.97 | 69.35 | 3.01 | 0.08 | 14.80 | 21.13 | 31.88 | 53.23 | 3.88 | 0.14 | 1.39 | (1.016–1.901) | 0.03 |
| male | 34.40 | 43.63 | 45.92 | 50.00 | 4.04 | 0.04 | 55.20 | 66.67 | 61.22 | 66.67 | 3.09 | 0.07 | 13.60 | 20.59 | 30.61 | 33.33 | 3.76 | 0.15 | 1.47 | (1.008–2.158) | 0.04 | |
| female | 36.43 | 42.50 | 32.50 | 40.43 | 0.79 | 0.37 | 57.75 | 62.50 | 50.00 | 70.21 | 0.24 | 0.62 | 16.90 | 22.50 | 35.00 | 59.57 | 0.57 | 0.75 | 1.24 | (0.709–2.170) | 0.44 | |
Abbreviations: CD, schizophrenia subjects classified as having generalized cognitive deficit; CI, confidence interval; CS, schizophrenia subjects classified as cognitively spared; HC, healthy controls; SZ, schizophrenia subjects; MAF, minor allele carrier frequency (T:C); MCF, minor carrier frequency (TT:TC/CC); MGF, minor genotypic frequency (TT:TC:CC); HWE, Hardy–Weinberg equilibrium. Significant values are in bold.