TABLE 6.
In vitro activity of meropenem alone and combined with xeruborbactam at 4 and 8 µg/mL and comparator BLI combination agents against carbapenem-resistant strains of Enterobacterales with cefepime-taniborbactam MIC >8 µg/mL
| MEM | MEM + XER (4) | MEM + XER (8) | FEP | FEP + TAN (4) | CAZ + AVI | |
|---|---|---|---|---|---|---|
| All (N = 156) | ||||||
| MIC50 | >64 | 2 | 0.5 | 64 | 32 | >64 |
| MIC90 | >64 | 32 | 8 | >64 | >64 | >64 |
| MBL negative (N = 34) | ||||||
| MIC50 | 16 | 0.5 | 0.25 | 64 | 16 | 4 |
| MIC90 | >64 | 8 | 4 | >64 | 64 | 32 |
| KPC and OXA-48 (N = 12) | ||||||
| MIC50 | 32 | 0.5 | 0.25 | 64 | 16 | 2 |
| MIC90 | >64 | 16 | 8 | >64 | 64 | 64 |
| Non-CP CRE (N = 22) | ||||||
| MIC50 | 16 | 1 | 0.5 | 64 | 32 | 2 |
| MIC90 | 32 | 8 | 4 | >64 | 64 | 32 |
| All MBL (N = 129) | ||||||
| MIC50 | >64 | 4 | 0.5 | 64 | 32 | >64 |
| MIC90 | >64 | 32 | 8 | >64 | >64 | >64 |
| NDN (N = 101) | ||||||
| MIC50 | >64 | 4 | 1 | 64 | 32 | >64 |
| MIC90 | >64 | 32 | 8 | >64 | >64 | >64 |
| VIM (N = 8) | ||||||
| MIC50 | >64 | 2 | 0.25 | >64 | 16 | >64 |
| IMP (N = 20) | ||||||
| MIC50 | 16 | 0.5 | ≤0.06 | 32 | 32 | >64 |
| MIC90 | 64 | 16 | 4 | >64 | >64 | >64 |